• Signed the ICF and Age ≥ 18 years old, either sex.

• ECOG score of 0-1.

• Life expectancy \> 3 months.

• Histopathologically or cytopathologically confirmed intrahepatic cholangiocarcinoma with unresectable, recurrent or metastatic (AJCC 2017, 8th edition, TNM stage IV) tumor that has progressed following at least one line of chemotherapy and progression/recurrence within 6 months after neoadjuvant/adjuvant chemotherapy may be included.

• FGFR2 fusion /rearrangement as confirmed by the central laboratory.

• At least one measurable lesion at screening as target lesion per RECIST 1.1.

• Organ functions meeting the protocol requirements.

• Contraception according to the protocol requirements.