• Diagnosis of pCCA (transcatheter biopsy or brush cytology, CA 19-9 \> 100 mg/mL and/or a mass on cross-sectional imaging with a malignant appearing stricture on cholangiography, or biliary ploidy with a malignant appearing stricture on cholangiography)

• Disease considered unsuitable for hepatic resection based on tumor location and extent or underlying liver dysfunction

• Absence of major vascular invasion, extrahepatic disease, or involvement of regional lymph nodes detected on radiological study

• No evidence of extrahepatic metastatic disease after chest-abdomen-pelvis CT and PET-MR (or PET-CT)

• Unresectable tumor above cystic duct (pancreatoduodenectomy for microscopic involvement of CBD) or resectable pCCA arising in PSC

• Radial tumor diameter \<3 cm

• At least six months have passed since the first diagnosis of pCCA to the date of inclusion on the liver transplant waiting list

• The patient has received at least six months of standard of care (SOC) chemotherapy, achieving disease stability or partial response (according to RECIST criteria version 1.1) at the time of listing for transplantation

• Absence of medical or surgical contraindication to liver transplantation

• Signed informed consent, and expected patient cooperation for treatment and follow-up, must be obtained and documented according to good clinical practice and national/local regulations