• Histological diagnosis of iCCA (biopsy-proven tumor)

• Either first diagnosis or post-resection recurrence (occurring ≥ 6 months after resection)

• Unresectability assessment due to tumor location (leading to insufficient live remnant with/out implementation of hypertrophic parenchymal techniques) or underlying liver disease. Non-resectability assessed by an expert surgical team with experience on both resection and transplantation (centralized at INT Milan).

• Age between 18 and 70 years

• No macrovascular tumor invasion (NB: portal vein and/or hepatic vein occlusion from the external tumor compression and classified as encasement could be considered after expert radiology review)

• No extrahepatic spread

• Disease stability for at least 6 months

• CA 19-9 \< 200 u/ml at transplant listing in absence of jaundice

• No medical and surgical contraindications to liver transplantation

• Good performance status, Eastern Cooperative Oncology Group (ECOG) 0 or 1

• No concomitant malignancies or history of other malignancies in the previous 5 years

• Written informed consent