Find Cholangiocarcinoma (Bile Duct Cancer) Clinical Trials Near You
A Phase 2, Open-Label, Single-Arm Study of Lirafugratinib in Patients With Previously Treated, Unresectable, Locally Advanced or Metastatic Solid Tumors (Excluding Cholangiocarcinoma) With FGFR2 Fusion or Rearrangement
Status: Recruiting
Location: See all (19) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
The goal of this clinical trial is to evaluate if lirafugratinib is efficacious and safe to treat adult patients with previously treated, unresectable, locally advanced or metastatic solid tumors (excluding cholangiocarcinoma) harboring FGFR2 fusion or rearrangement. Participants will: * Take lirafugratinib regularly as instructed by their study doctor. * Visit the clinic as instructed for checkups and tests. * Keep a diary recording each time a dose of lirafugratinib is taken.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Unresectable, locally advanced, or metastatic solid tumor (other than CCA).
• Documented FGFR2 gene fusion or rearrangement per local testing of blood and/or tumor.
• Patient must have measurable disease per RECIST v1.1• Patient has ECOG performance status of 0-1.
• Previously (\>30 days) treated with ≥1 line of systemic therapy including chemotherapy (e.g., gemcitabine/cisplatin), immunotherapy, radiation therapy, or other approved therapies.
• Subject has not received prior treatment with an FGFRi.
Locations
United States
Arizona
Mayo Clinic
NOT_YET_RECRUITING
Phoenix
Florida
Mayo Clinic
NOT_YET_RECRUITING
Jacksonville
Moffitt Cancer Center
RECRUITING
Tampa
Illinois
University of Chicago Medical Center
NOT_YET_RECRUITING
Chicago
Massachusetts
Massachusetts General Hospital
NOT_YET_RECRUITING
Boston
Minnesota
Mayo Clinic
NOT_YET_RECRUITING
Rochester
Texas
The University of Texas M.D. Anderson Cancer Center
NOT_YET_RECRUITING
Houston
Other Locations
France
Institut Bergonie
NOT_YET_RECRUITING
Bordeaux
Centre Georges François Leclerc
NOT_YET_RECRUITING
Dijon
Centre Leon Berard
NOT_YET_RECRUITING
Lyon
Gustave Roussy Cancer Campus
NOT_YET_RECRUITING
Paris
Republic of Korea
Samsung Medical Center
NOT_YET_RECRUITING
Seoul
Seoul National University Hospital
NOT_YET_RECRUITING
Seoul
Spain
START Barcelona-Hospital HM Nou Delfos
NOT_YET_RECRUITING
Barcelona
Hospital Universitario Fundación Jiménez Díaz- START MADRID