• Willing and able to give written informed consent for participation in the trial and able to comply with all trial procedures and requirements.

• Male or female participant aged 18 to 75 years, inclusive, at the screening visit.

• Body mass index (BMI) ≥ 19 and \< 40.0 kg/m2 at the time of the screening visit.

• Women of childbearing potential (WOCBP) must practice abstinence from heterosexual intercourse (only allowed when this is the preferred and usual lifestyle of the participant) or must agree to use a highly effective method of contraception with a failure rate of \< 1 % to prevent pregnancy from at least 2 weeks prior to administration of tracer for at least 1 week after the PET imaging examination (or for at least 1 weak after the last PET imaging examination for those participants undergoing test/retest PET imaging). In addition, any male partner of a female participant must, unless he has undergone vasectomy, agree to use a condom during the same time period.

• The following are considered highly effective methods of contraception:

⁃ combined (estrogen and progestogen-containing) hormonal contraception associated with inhibition of ovulation (oral, intravaginal, transdermal),

⁃ progestogen-only hormonal contraception associated with inhibition of ovulation (oral, injectable, implantable),

⁃ intra-uterine device \[IUD\]or intra-uterine hormone-releasing system \[IUS\]) WOCBP must refrain from donating eggs until 3 months after the last tracer administration.

• WOCBP with an exclusive male partner who has undergone vasectomy may choose not to use contraceptives.

• Women of non-childbearing potential are pre-menopausal females who have undergone any of the following surgical procedures; hysterectomy, bilateral salpingectomy, or bilateral oophorectomy, or who are post-menopausal defined as 12 months of amenorrhea (in questionable cases a blood sample with detection of follicle-stimulating hormone \[FSH\] \>25 IU/L is confirmatory).

• Male participants must be willing to use condom or be vasectomized or practice sexual abstinence from heterosexual intercourse (only allowed when this is the preferred and usual lifestyle of the participant) to prevent pregnancy and drug exposure of a partner and refrain from donating sperm from the administration of tracer until 3 months after the administration of tracer. Any female partner of a non-vasectomized male participant who is of childbearing potential must use contraceptive methods with a failure rate of \< 1% to prevent pregnancy (see above) from at least 2 weeks prior to administration of tracer to 4 weeks after administration of tracer.

• Cohort-specific inclusion criteria:

• Cohort 1 (healthy participants)

• Medically healthy participant without abnormal clinically significant medical history, physical findings, vital signs, ECG, and laboratory values at the time of the screening visit, as judged by the Investigator.

• Cohort 2 (presumed MASH patients) MASH diagnosis based on non-invasive assessments. Participants should have a high level of disease activity with regards to pro-peptide of type III collagen (ProC3) as a marker of ongoing fibrogenesis.

• Steatosis according to biopsy, radiology, or controlled attenuation parameter (CAP) (≥ 280 dB/M 8), assessments ≤ 24 weeks prior to the screening visit.

• At least 1 cardiometabolic criteria from the following list:

• A. BMI ≥ 25 kg/m2 \[23 Asia\] OR waist circumference (WC) \> 94 cm (M) 80 cm (F) OR ethnicity adjusted, B. Fasting serum glucose ≥ 5.6 mmol/L \[100 mg/dL\] OR 2-hour post-load glucose levels ≥ 7.8 mmol/L \[≥ 140 mg/dL\] OR HbA1c ≥ 5.7% \[39 mmol/L) OR type 2 diabetes OR treatment for type 2 diabetes, C. Blood pressure ≥ 130/85 mmHg OR specific antihypertensive drug treatment, D. Plasma triglycerides ≥ 1.70 mmol/L \[150 mg/dL\] OR lipid-lowering treatment, E. Plasma high-density lipoprotein (HDL)-cholesterol ≤ 1.0 mmol/L \[40 mg/dL\] (M) and ≤ 1.3 mmol/L \[50 mg/dL\] (F) OR lipid-lowering treatment.

• ProC3 ≥ 12.6 ng/mL. Cohort 3 (verified MASH patients) MASH diagnosis based on historical liver biopsy. Participants should have a high level of disease activity with regards to ProC3 as a marker of ongoing fibrogenesis, to allow for correlation to PET-tracer uptake.

• Evidence of steatosis according to biopsy, radiology, or CAP (≥ 280 dB/M) or MRI-PDFF, assessments ≤ 24 weeks prior to the screening visit.

⁃ At least 1 cardiometabolic criteria from the following list:

⁃ A. BMI ≥ 25 kg/m2 \[23 Asia\] OR WC \> 94 cm (M) 80 cm (F) OR ethnicity adjusted, B. Fasting serum glucose ≥ 5.6 mmol/L \[100 mg/dL\] OR 2-hour post-load glucose levels ≥ 7.8 mmol/L \[≥ 140 mg/dL\] OR HbA1c ≥ 5.7% \[39 mmol/L) OR type 2 diabetes OR treatment for type 2 diabetes, C. Blood pressure ≥ 130/85 mmHg OR specific antihypertensive drug treatment, D. Plasma triglycerides ≥ 1.70 mmol/L \[150 mg/dL\] lipid-lowering treatment, E. Plasma HDL-cholesterol ≤ 1.0 mmol/L \[40 mg/dL\] (M) and ≤ 1.3 mmol/L \[50 mg/dL\] (F) OR lipid-lowering treatment.

⁃ Historical liver biopsy 24 weeks to 4 weeks prior to inclusion with histologically proven metabolic dysfunction-associated steatotic liver disease (MASLD).

⁃ ProC3 ≥ 12.6 ng/mL. Cohort 4 (fibrostenotic CD patients)

⁃ Fibrostenotic CD as evidenced by persistent luminal narrowing with or without obstructive symptoms as assessed with MRI, ≤ 24 weeks prior to the screening visit OR fibrostenotic CD by positive colonoscopy up to 24 weeks prior to the screening visit.

⁃ Crohn's disease activity index (CDAI) \< 150

⁃ Calprotectin \< 250

⁃ C-reactive protein (CRP) \< 20 Cohort 5 (PSC patients)

⁃ Large duct PSC, including intrahepatic bile duct involvement, according to MRI/MRCP.

⁃ ProC3 ≥ 12.6 ng/mL