Percutaneous or Endoscopic Gallbladder Drainage: The PEG Trial
This is a randomized trial of patients with acute calculous cholecystitis who are never-surgery candidates. Patients will be randomized to one of two treatment groups, percutaneous cholecystostomy or endoscopic ultrasound-guided drainage. The aim of the study is to compare between these two treatment methods, the treatment outcomes and quality of life over a follow-up duration of 36 months.
• Patients with suspected or confirmed acute calculous cholecystitis, diagnosed per Tokyo guidelines
• Age ≥ 18 years
• Patients due to severe comorbidity who are deemed to be never-surgery candidates by the multidisciplinary team or patients who refuse to undergo surgery.
• Patients can undergo EUS-guided drainage and percutaneous cholecystostomy tube placement.
• Written informed consent by the patient or guardian who can understand the nature and possible consequences of participation in the study.