Learn About Chronic Idiopathic Constipation

What is the definition of Chronic Idiopathic Constipation (CIC)?
Chronic idiopathic (of unknown cause) constipation is a persistent condition that mainly affects females and older adults and is characterized by infrequent, hard, and lumpy stools that are extremely difficult to pass. This creates a buildup of stool in the colon that causes extreme abdominal and pelvic pain. While the cause is unknown, chronic idiopathic constipation may be triggered by reduced fluid and fiber intake; the use of certain medications, such as antihistamines, antipsychotic medications, opioids, general anesthetics, and antiparkinsonian drugs; changes in the colon; rectocele (rectum bulging into vagina); rectal prolapse (rectum protrudes through the anus); or dyssynergic dysfunction (disorder of muscles and sphincters that control defecation).
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What are the symptoms of Chronic Idiopathic Constipation (CIC)?
Symptoms of chronic idiopathic constipation may include chronic constipation (fewer than three bowel movements a week) that persists for six months or more with hard stools; a feeling of incomplete bowel evacuation; a sensation of a blockage in the rectum or anus; straining upon defecation; abdominal pain and bloating; back pain; poor appetite; a general feeling of being unwell (malaise); and the necessity of using the hands to facilitate defecation.
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What are the current treatments for Chronic Idiopathic Constipation (CIC)?
Treatments for chronic idiopathic constipation include laxatives, such as milk of magnesia, lactulose, and polyethylene glycol (PEG); glycerin suppositories; enemas; stimulant laxatives, such as bisacodyl, glycerol, or sodium picosulfate; linaclotide; prucalopride; fiber laxatives, such as psyllium, calcium polycarbophil, inulin, and maltodextrin; prucalopride; velusetrag; lubiprostone; linaclotide; increased dietary fiber and water intake; probiotics; physical exercise; and biofeedback training.
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What are the latest Chronic Idiopathic Constipation Clinical Trials?
A Phase 3, Multicenter, Randomized, Double-blind, Parallel-group, Safety and Efficacy Study of Linaclotide Versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, With Functional Constipation (FC) With a 24-week Open-label Treatment Extension

Summary: Functional constipation (FC) is a common healthcare problem in children of all ages, potentially due to genetic predisposition, inadequate fiber and fluid intake, and immobility. Currently, there are no pharmacological therapies approved for the treatment of FC. This study will assess adverse events and change in disease activity with linaclotide therapy in participants with FC. Linaclotide is an ...

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Phase 3, Multicenter, Randomized Study With 2 Different Doses of Prucalopride Administered to Male and Female Pediatric Subjects Aged 6 Months to 17 Years With Functional Constipation, Consisting of a 12-week Double-blind, Placebo-controlled Part (Part A) to Evaluate Efficacy and Safety Followed by a 36-week Double-blind Extension Part (Part B) to Document Long-term Safety up to Week 48

Summary: Functional constipation is a condition when it is very hard to pass a stool that is not due to any other health problem or to medicines being taken. This condition is more common in children and teenagers. This study has 2 parts: The main aim of the 1st part of the study is to learn if a medicine called prucalopride can improve bowel movements in children and teenagers with functional constipation...

What are the Latest Advances for Chronic Idiopathic Constipation?
The use of two Comfort Young Child Formulas in the dietary management of toddlers with functional constipation: a randomized controlled trial.
Pharmacotherapeutic advances for chronic idiopathic constipation in adults.
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Minimal clinically important difference of the frequency of bowel movement for patients with chronic severe functional constipation treated with acupuncture.