A Single-center, Non-randomized, Uncontrolled Pilot Study on Hypothermic Machine Perfusion With Omnisol Preservation Solution of Deceased Donor Kidneys Prior to Transplantation
Insufficient availability of organs from brain dead (DBD) and living donors has necessitated increased use of less than optimal organs from donation after cardiac death (DCD) or from extended criteria donors. Preservation of DCD organs using the current clinically applied preservation solutions is associated with up to 73% incidence of delayed graft function, highlighting the need for new preservation solutions designed to improve early graft function. Omnisol is expected to result in equivalent or improved kidney preservation as compared to currently marketed organ preservation solutions used for HMP.
• Donor age \> 18 years
• Brain Death (DBD) or Circulatory Death \< 50 years (DCD\<50)
• Accepted for transplantation according to local criteria
• Male or female, age \> 18 years
• Able and willing to comply with all study requirements (in opinion of investigator or deputy)
• General inclusion criteria applicable to kidney transplantation:
‣ Listed for renal transplantation due to end stage renal disease on the Eurotransplant (ET) list
⁃ Fit to proceed with kidney transplantation (in opinion of investigator or deputy)