Lung Health of Early Chronic Obstructive Pulmonary Disease: A Multi-center Cohort Study
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Behavioral
Study Type: Observational
SUMMARY
This is a multi-center, prospective, cohort study in early COPD patients. This study aims to elucidate the lung function decline and its association with smoking and other risk factors. Other biomarkers and image markers from chest CT scan are also analyzed to investigate the lung function in early COPD patients.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 35
Maximum Age: 75
Healthy Volunteers: t
View:
• Gender: male or female
• Age: 35-75 years old
• post-bronchodilator spirometry: FEV1/FVC \< 0.8 and FEV1%pred ≥80%
Locations
Other Locations
China
China-Japan Friendship Hospital
RECRUITING
Beijing
Affiliated Hospital of Zunyi Medical University
RECRUITING
Zunyi
Contact Information
Primary
Ke Huang, M.D.
huangke_zryy@163.com
+86-010-84206276
Backup
Jieping Lei, PhD
jiepinglei@126.com
+86-010-84206279
Time Frame
Start Date: 2022-08-01
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 1550
Treatments
Smokers with Pre-COPD
Smoking history ≥ 10 pack-years 0.7≤ FEV1/FVC\<0.8 and FEV1%pred ≥ 80% (post-bronchodilator)
Smokers with Mild-COPD
Smoking history ≥ 10 pack-years FEV1/FVC\<0.7 and FEV1%pred ≥ 80% (post-bronchodilator)
Non-Smokers with Pre-COPD
Smoking history \< 10 pack-years or never-smokers 0.7≤ FEV1/FVC\<0.8 and FEV1%pred ≥ 80% (post-bronchodilator)
Non-Smokers with Mild-COPD
Smoking history \< 10 pack-years or never-smokers FEV1/FVC\<0.7 and FEV1%pred ≥ 80% (post-bronchodilator)
Healthy Controls
Healthy volunteers without smoking history FEV1/FVC ≥ 0.8 and FEV1%pred ≥ 80% (post-bronchodilator)
Related Therapeutic Areas
Sponsors
Collaborators: Chinese Academy of Medical Sciences
Leads: Ting YANG