Chronic Obstructive Pulmonary Disease (COPD) Clinical Trials

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Monitoring of the End-tidal Carbon Dioxide (EtCO2 ) as a Severity Criterion in COPD Exacerbations: a Prospective Observational Study

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

Although we know that these numbers are underestimated, Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease that affects between 8 and 12% of adults. According to a 2020 WHO report, it is the third most common cause of mortality in developed countries. This disease is punctuated by exacerbations associated with an 8% mortality of hospitalized patients, increased to 24% when the patient is admitted to intensive care unit. Early detection and treatment of these exacerbations appears to be essential to improve patient survival. End-tidal carbon dioxide (EtCO2) is used to assess a patient's respiratory and hemodynamic status. Indeed, EtCO2 is a non-invasive measure that could allow the estimation of arterial carbon dioxide (PaCO2) without performing blood gases, an arterial blood sampling, classically at the radial artery. This study aimed to find an EtCO2 value which at the time of the initial management, would be predictive of a severe COPD exacerbation, as well as PaCO2.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• All patient presenting to the emergency department with acute dyspnea and with a history of COPD documented or reported by the patient and/or family

• Male or female≥18 years old who did not oppose to participating in the study

Locations
Other Locations
France
CHU Grenoble Alpes
RECRUITING
Grenoble
Hospices Civils de Lyon
RECRUITING
Lyon
Contact Information
Primary
Nicolas SEGOND, MD
nsegond@chu-grenoble.fr
+33476766784
Backup
Prudence MABIALA MAKELE, PhD
pmabialamakele@chu-grenoble.fr
+33476766784
Time Frame
Start Date: 2023-03-03
Estimated Completion Date: 2026-12-03
Participants
Target number of participants: 240
Treatments
Patient admitted for acute Exacerbation of Chronic Obstructive Pulmonary Disease
Patient admitted for acute Exacerbation of COPD. The measurement of EtCO2 will be performed at the emergency department
Sponsors
Collaborators: Hospices Civils de Lyon
Leads: University Hospital, Grenoble

This content was sourced from clinicaltrials.gov

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