⁃ Healthy participants (Part A)

• Participant must be 18 to 65 years of age inclusive.

• Participants who are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, and cardiac monitoring

• Body weight within the range 50-110 kilogram (kg) (inclusive)

• Body mass index (BMI) within the range 19.5-32 kilogram per square meter (kg/m\^2)

• Male and/or female of non-childbearing potential

⁃ Participants with Chronic Obstructive Pulmonary Disorder (COPD) (Part B)

• Participant must be 40 to 75 years of age inclusive.

• Body weight within the range 50-110 kg (inclusive)

• BMI within the range 19.5-32 kg/m\^2

• Participant has a confirmed diagnosis of COPD for greater than (\>)12 months

• Participants must present with a measured post-salbutamol Forced expiratory volume in 1 second/Forced vital capacity (FEV1/FVC) ratio of less than (\<) 0.70 at screening to confirm the diagnosis of COPD and a measured post-salbutamol FEV1 greater than or equal to (\>=) 40% of predicted normal values.

• Participants must have a well-documented requirement for optimized standard of care background therapy that includes daily inhaled medication.

• A peripheral blood eosinophil count of \>=150 cells/microliter (mcL) at screening

• Former cigarette smokers with a history of cigarette smoking of \>=10 pack-years at screening current smokers (includes the use of any type of nicotine containing product), or non-smokers are permitted

• Male and/or female of non-childbearing potential.