Associates of, and Time to Recovery From, Eosinopenia in Severe COPD Exacerbation
The goals of this observational study are to identify factors independently associated with admission eosinopenia in patients with a severe exacerbation of chronic obstructive pulmonary disease (COPD) and to determine when blood eosinophil count (BEC) will recover to baseline stable state in patients who are admitted to hospital with a severe exacerbation of COPD and associated eosinopenia. The main aims of the study are to: 1. Identify demographic, physiological and clinical factors independently associated with admission eosinopenia in patients with a severe exacerbation of COPD 2. Assess the time to recovery from eosinopenia to stable BEC following a severe exacerbation of COPD
• Admitted to hospital with primary clinical diagnosis of exacerbation of COPD\*
• Smoking history of at least 10 pack years
• Airflow obstruction: FEV1/FVC ratio \< 0.7 confirmed on historic or inpatient spirometry
• Capacity to give informed consent to participate
• Eosinopenia on admission
• Uneventful recovery\*
⁃ Eosinopenia on admission who do not receive a further course of systemic corticosteroids or require emergency hospital admission for an acute illness in the six weeks following admission to hospital with a severe exacerbation of COPD.