Using Large Language Models Such As GPT-4 to Assess Guideline Adherence in Patients with Chronic Obstructive Pulmonary Disease

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

According to studies in the US and the Netherlands, 33-40% of patients with chronic conditions receive care that does not follow guideline recommendations. These findings have also been demonstrated in the management of COPD. This leads to under- or over-treatment of patients and, in the case of COPD, to exacerbations and hospitalisations. These exacerbations are a significant clinical problem, affecting patient's lung function, quality of life and mortality. They are also a burden on the healthcare system. Technological advances in artificial intelligence offer the opportunity to address these issues in COPD management. In the past year, there have been remarkable innovations in the field of natural language processing, especially through large language models such as GPT-4 from OpenAI and Bard or Gemini from Google. These models offer an opportunity to improve the implementation of evidence-based care in clinical practice. This study is a prospective, randomised trial that will compare therapy on discharge for patients with COPD. One arm will receive no intervention, while the other arm will receive a treatment recommendation from an LLM. The study will compare the percentage of patients treated according to the guideline.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Diagnosis of COPD

• Consent

• Discharge after hospitalization

Locations
Other Locations
Germany
Charité University
RECRUITING
Berlin
Contact Information
Primary
Matthias Gröschel, MD PhD
matthias.groeschel@charite.de
+4915906714937
Backup
Sylvia Hartmann, MD MPH
Time Frame
Start Date: 2024-05-15
Estimated Completion Date: 2025-03-30
Participants
Target number of participants: 70
Treatments
No_intervention: No Intervention
This arm will be treated as usual. No intervention will be performed.
Active_comparator: LLM Assessement
During hospital stay and after written informed consent, an LLM is asked to indicate if the treatment the patient receives is guideline-concordant. The information is ascertained by two study physicians (human-in-the-loop) and later provided to the treating physician who can recommend a change in therapy to the patient (outside of the study).
Sponsors
Leads: Charite University, Berlin, Germany

This content was sourced from clinicaltrials.gov