Occult Cardiovascular Disease With Chronic Exposure to Secondhand Tobacco Smoke
This is a double-blind randomized placebo-controlled crossover clinical trial of efficacy and safety of an FDA-approved angiotensin receptor blocker (losartan) to improve cardiopulmonary outcomes in individuals with pre-Chronic Obstructive Pulmonary Disease (COPD) due to prolonged exposure to secondhand tobacco smoke.
• Must be able to understand and provide informed consent.
• Adults \>= 40 years of age.
• Must have a history of occupational exposure to secondhand tobacco smoke for at least 5 years such as flight attendants who worked for airlines before the smoking ban on aircrafts went into effect or casino workers who worked at casinos with no smoke-free policies.
• Must have never smoked or have a remote history of light smoking defined as follows:
‣ Lifetime smoking history equivalent to \< 1 pack-year and
⁃ No smoking history for \>= 20 years at the time of enrollment.