Physical Activity and Fibrosing Interstitial Lung Disease

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Fibrotic interstitial lungs diseases (ILD) are a group of chronic and rare diseases characterized by an altered blood oxygenation in the lung, leading to dyspnea and physical limitation. Physical training is efficient to fight vicious circle of physical deconditioning observed in ILD. Eccentric cycling is an interesting modality of endurance training, allowing better exercise tolerance and adherence while developing cardiorespiratory function. Feasibility and efficacity of eccentric cycling were shown in chronic obstructive pulmonary disease but never in ILD. The primary aim of our work is to compare concentric and eccentric cycling training on physical capacities in ILD. Moreover, we will study the effects of training on the different steps of oxygen transport at exercise, from the lung to the muscles through the blood transport. Our second goal is then to characterize the physiological mechanisms underlying the benefits of exercising in ILD patients. Evaluations will be led during one year to study the long-term effects of training

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patient aged ≥ 18 years

• Fibrosing PID with fibrosis score \> 10% of lung volume on chest CT scan

• Be able to attend physical reconditioning 3 times a week

• Be affiliated to a health insurance scheme

• Sign informed consent form

Locations
Other Locations
France
Exercise and Sports Medicine Department
RECRUITING
Bobigny
Time Frame
Start Date: 2023-11-30
Estimated Completion Date: 2026-01-30
Participants
Target number of participants: 60
Treatments
Experimental: Training on eccentric ergocycle (experimental group)
In eccentric cycling, pedals push against the user's feet in the opposite direction, user has to slow down pedals and quadriceps muscles lengthen during contraction.
Active_comparator: Training on concentric ergocycle (control group)
In concentric cycling, quadriceps contract to push pedals.
Sponsors
Leads: Assistance Publique - Hôpitaux de Paris

This content was sourced from clinicaltrials.gov