Chronic Obstructive Pulmonary Disease (COPD) Clinical Trials

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The Effect of the High-intensity Resistance Training in COPD Patients Recovering From Hospital Exacerbation: a Pilot Study

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

After a COPD exacerbation, many individuals experience severe weakness in the leg muscles, especially the quadriceps. This weakness can make daily activities difficult and slow down recovery. Traditional respiratory rehabilitation usually focuses on endurance training, which is effective but often hard to tolerate soon after an exacerbation due to persistent symptoms and limited functional capacity. This study aims to compare two early rehabilitation approaches during recovery from a COPD exacerbation: a maximal strength training (MST) programme using high loads and few repetitions, and a traditional endurance-based training programme. The investigators aim to determine whether MST is easier to tolerate, especially in terms of breathlessness, and whether MST can improve muscle strength, efficiency, and overall exercise tolerance as well as or better than endurance training. The results will help identify the most suitable rehabilitation strategy for individuals recovering from a COPD exacerbation, particularly for those who struggle with high-intensity endurance exercise.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• COPD diagnosis according to the GOLD guidelines \[11\] with FEV1/FVC \<70%

• Stable clinical condition (pH\>7.30) \[11\]

• Hospital discharge within 3 weeks from an event of hospitalization due to an acute exacerbation of COPD.

• Absence of significant motor disability, described by the possibility of performing the 6MWT.

Locations
Other Locations
Italy
ICS Maugeri IRCCS, Respiratory rehabilitation of the Institute of Lumezzane
RECRUITING
Lumezzane
Contact Information
Primary
Mara Paneroni, PhD, MSc
mara.paneroni@icsmaugeri.it
+0039+030+8253
Backup
Tiziana Bachetti, Pharm
tiziana.bachetti@icsmaugeri.it
+0039+0382+593
Time Frame
Start Date: 2025-10-30
Estimated Completion Date: 2028-05
Participants
Target number of participants: 64
Treatments
Experimental: High-Intensity Resistance Training (HIRT)
This is the group performing high-intensity strength training on the leg press, combined with low-intensity cycling; it is the intervention study group.
Active_comparator: High-Intensity Endurance Training (HIET)
This is the group performing high-intensity endurance training on the cycle ergometer, combined with low-intensity leg press; it is the active comparator study group (Active Comparator).
Sponsors
Collaborators: University of Verona, Italy
Leads: Istituti Clinici Scientifici Maugeri SpA

This content was sourced from clinicaltrials.gov