Chronic Obstructive Pulmonary Disease (COPD) Clinical Trials

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Prospective Multicenter Cohort to Discriminate Asthma Versus Chronic Obstructive Pulmonary Disease and Predict Treatment Response Using Quantitative Chest CT and Multi-Omics

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

This study aims to improve the diagnosis and treatment prediction of asthma and chronic obstructive pulmonary disease (COPD) by combining quantitative chest computed tomography (CT) imaging with multi-omics data. Adults with asthma or COPD will be enrolled and undergo routine clinical evaluations, pulmonary function tests, blood tests, and chest CT scans. Additional samples, such as sputum and microbiome specimens, may also be collected. No experimental drugs or devices will be administered as part of this study. Researchers will analyze CT imaging features together with clinical, laboratory, and biological data to better distinguish asthma from COPD and to identify factors that may predict treatment response. The findings are expected to contribute to more precise and personalized management of chronic airway diseases.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 19
Healthy Volunteers: f
View:

• Age ≥19 years

• COPD group: post-bronchodilator FEV1/FVC \< 0.70

• Asthma group: clinically confirmed diagnosis of asthma by a physician

• Able to provide voluntary written informed consent

Locations
Other Locations
Republic of Korea
Korea University Guro Hospital
RECRUITING
Seoul
Contact Information
Primary
Sang Hyuk Kim, MD
gost702@korea.ac.kr
+82-2-2626-1659
Backup
Clinical Research Office Korea University Guro Hospital
kumc.guro.rst@kumc.or.kr
+82-2-2626-1659
Time Frame
Start Date: 2025-12-22
Estimated Completion Date: 2027-12-22
Participants
Target number of participants: 200
Treatments
Prospective Asthma-COPD Cohort
This cohort includes adults with physician-diagnosed asthma or chronic obstructive pulmonary disease (COPD) who are enrolled in a prospective, observational study. Participants undergo routine clinical assessments, pulmonary function testing, blood sampling, and chest computed tomography (CT) imaging as part of standard care and study-related data collection. No investigational drugs or medical devices are administered. Data from clinical evaluations, imaging, and biospecimens (e.g., blood and sputum) will be analyzed to characterize disease features and predict treatment response.
Sponsors
Leads: Korea University Guro Hospital
Collaborators: The Korean Academy of Tuberculosis and Respiratory Diseases

This content was sourced from clinicaltrials.gov