Olfactory Cleft Obstruction and Electrophysiological Olfactory Bulb Generated Beta Field Potentials Predict Olfactory Restoration by Dupilumab in CRSwNP Patients.

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Observational
SUMMARY

The goal of this observational study is to learn what can predict the return of the sense of smell in patients with chronic rhinosinusitis with nasal polyps being treated with dupilumab. The main questions it aims to answer are: 1. Does obstruction of the olfactory cleft predict return of the sense of smell? 2. Do electrophysiological signals generated by breathing and sniffing behavior predict return of the sense of smell? Participants starting dupilumab will undergo assessment for their degree of olfactory cleft obstruction, and an electrophysiologic assessment of their olfactory cleft and be followed over 6 months of treatment with dupilumab.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:

• Well documented history of CRSwNP

• BSIT age/sex classified as abnormal score

• Self-reported stable olfactory deficit of moderate to severe quality \> 3 months

• Prior endoscopic sinus surgery \>3 months, \<10 years prior

Locations
United States
Illinois
Northwestern University Feinberg School of Medicine
RECRUITING
Chicago
Contact Information
Primary
Clinical Coordinator
aditi.agarwal@northwestern.edu
312 6958182
Backup
Bruce Tan, MD
btan@nm.org
312 6958182
Time Frame
Start Date: 2025-05-01
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 30
Treatments
Dupilumab Treatment
Patients who had prior endoscopic sinus surgery for CRSwNP with persistent smell loss initiating dupilumab
Sponsors
Collaborators: Sanofi
Leads: Northwestern University

This content was sourced from clinicaltrials.gov