Clinical Evaluation of Triamcinolone Acetonide-loaded Nanoparticles For Nasal Postoperative Application
This randomised, single-masked, parallel-group clinical trial will evaluate the efficacy and safety of a topical triamcinolone acetonide-loaded polymeric nanocapsule formulation for postoperative care following endoscopic nasal surgery. Participants will receive either the investigational triamcinolone acetonide-loaded nanocapsule formulation or standard normal saline nasal irrigation. Postoperative nasal healing, inflammation, patient-reported sinonasal symptoms, postoperative complications, and corticosteroid-related adverse effects will be compared between the two groups.
• Adults aged 18 to 60 years.
• Patients scheduled to undergo one of the following procedures:
• Functional endoscopic sinus surgery
• Endoscopic turbinoplasty
• Endoscopic septoplasty
• Diagnosis of chronic rhinosinusitis and/or nasal polyps requiring surgical intervention.
• Ability and willingness to provide written informed consent.
• Ability and willingness to comply with study treatment and scheduled follow-up visits.