• Age between 18 to 75 years old (including 18 and 75)

• Diagnosed as advanced classical hodgkin's lymphoma based on histopathology

• Subjects must be untreated (Ann Arbor Stage III/IV or Ann Arbor II with B symptoms along with mediastinal big tumor or extranodal changes)

• No receiving chemotherapy before enrollment

• Having at least one measurable lesions

• World health organization-Eastern Cooperative Oncology Group Performance Status (ECOG) 0-2

• Life expectancy no less than 3 months

• enough main organ function

• Pregnancy test within 7 days must be negative for women of childbearing period, and appropriate measures should be taken for contraception for women in childbearing period during the study and six months after this study

⁃ Agreeing to sign the written informed consents