Migraine and High Flow Oxygenotherapy at the Emergency Department

Who is this study for? Patients in the emergency department with migraine
What treatments are being studied? Oxygenotherapy
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

Migraine is a common pathology, affecting around 12% of the general population, up to 25% in some cohorts, as well as a significant part of the reasons for emergency room visits. Unlike cluster headaches, the use of high-flow oxygen therapy has not yet been validated in patients with migraine. However, several aspects of its pathophysiology, still studied to this day, suggest that the use of normobaric oxygen could have beneficial effects on migraine attacks: tissue hypoxia, cerebrovascular dysfunction with vasodilation, inflammation, etc. In addition, high-flow oxygen therapy has no significant side effects and almost no contraindication (mainly COPD and other chronic respiratory failure) Its use in the event of a migraine attack would thus allow less recourse to conventional analgesics (with significant side effects for some), a shorter stay in the emergency room, and therefore a benefit in terms of cost and relief for the patient. In this context, the sponsor wish to carry out a multicenter prospective interventional, single-blind randomized placebo-controlled in parallel groups study.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• 18 years old or more

• Affiliated to a french public health insurance

• ED admission for migraine evocative headache, regarding ICHD3 criterions

• written informed consent

Locations
Other Locations
France
CHU de Nice
RECRUITING
Nice
Contact Information
Primary
Julie CONTENTI
contenti.j@chu-ice.fr
+334.92.03.85.35
Backup
Céline OCCELLI
occelli.c@chu-nice.fr
+33492033204
Time Frame
Start Date: 2023-10-01
Estimated Completion Date: 2025-04
Participants
Target number of participants: 70
Treatments
Experimental: oxygenotherapy
Placebo_comparator: placebo air aerosol
Sponsors
Leads: Centre Hospitalier Universitaire de Nice

This content was sourced from clinicaltrials.gov