Advanced Endo-therapeutic Procedure : Registry-based Observational Study

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY

Advanced therapeutic endoscopy procedures are of increasing importance to provide minimal invasive treatment for GI diseases. The Centre Hospitalier de l'Université de Montréal as tertiary university center is dedicated to increase the availability of therapeutic endoscopy procedures for our population in Montreal and Quebec. Advanced endotherapeutic endoscopy can replace surgery for treatment of benign and malign GI diseases and the aim of this registry-based study is to improve quality related to advanced endotherapeutic endoscopy, as it will provide quantitative means to assess advanced endotherapeutic practice and may identify practices of low quality (possible intervention) or high quality (desired).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age \>18 years

• Presenting for an elective advanced therapeutic endoscopy (ESD, EMR, advanced polypectomy, POEM or Zenker treatment)

• Signed informed consent form

Locations
Other Locations
Canada
Centre Hospitalier Universitaire de Montréal (CHUM)
RECRUITING
Montreal
Contact Information
Primary
Daniel von Renteln, MD, PhD
daniel.von.renteln.med@ssss.gouv.qc.ca
514-890-8000
Backup
Samira Hanin
samira.hanin.chum@ssss.gouv.qc.ca
514-890-8000
Time Frame
Start Date: 2018-06-01
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 500
Treatments
Endoscopic mucosal resection (EMR)
It has become the standard treatment for superficial tumors of the gastrointestinal tract, either flat or sessile: precancerous lesions and superficial cancers with no or low ganglionic risk. The pre-injection of physiological serum detaches the lesion from the deep plane and allows, with great security, the resection of the mucosa, muscularis mucosae with part of the submucosa, whatever the size and location of the lesion. Compared to other techniques, it allows a histological analysis which dictates the subsequent conduct and the possible need for a complementary surgery.
Endoscopic mucosal dissection (ESD)
This technique uses submucosal injection and special knives to make a peri-lesional circumferential incision, followed by dissection through the submucosal sub-lesion.
Radio Frequency Ablation (RFA) and Argon Plasma Ablation (APC)
This is a mucosal thermo-destruction technique. It uses a generator that delivers a sinusoidal current of high frequency to a probe covered with bipolar electrodes in tight network ensuring a uniform diffusion of the thermal effect. The tissue penetration is superficial on 1mm, intended to eradicate the epithelium up to the muscularis mucosae. Circumferential or focal probes are used as a function of the length of the segment to be treated.
Per Oral Endoscopic Myotomy (POEM)
This technique allows a myotomy on the 8 cm of the lower esophagus extended on the gastric side of the cardia, totally endoscopically, after having approached and tunneled the esophageal submucosa.~Less invasive, it gradually replaces the pneumatic dilatation and surgical myotomy of Heller.~It requires a general anesthesia, an expert operator and a trained nursing team, ESD instruments, carbone dioxide insufflation.
Authors
Justin Côté-Daigneault, Audrey Weber, Simon Bouchard, Benoit Panzini, Mickael Bouin, Erik Deslandres
Related Therapeutic Areas
Viral Gastroenteritis
Colorectal Cancer
Sponsors
Leads: Centre hospitalier de l'Université de Montréal (CHUM)

This content was sourced from clinicaltrials.gov

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