The Value of Palliative Primary Tumor Resection in Colon Cancer Patients With Initially Unresectable Metastases After Induction Chemotherapy: a Prospective, Multicenter, Randomized Controlled Clinical Trial
The aim of this trial is to evaluate the value of palliative primary tumor resection in colon cancer patients with initially unresectable metastases and a positive response to induction chemotherapy which depends on gene testing. The primary endpoint is to evaluate overall survival.
• 75 years old
• ECOG (Eastern Cooperative Oncology Group) 0-1 and expected survival period for 6 months or more
• Pathological diagnosis of colon cancer adenocarcinoma
• At least one measurable objective tumor lesions which could be evaluated.
• Primary and metastatic tumors exist at the same time, and distant metastases are not resectable
• ANC≥1.5\*109/L；PLT≥90\*109/L；HB≥90g/L；TBI≤1.5(UNL); ALT、AST≤2.5ULN；Cr≤1.0(ULN) screening within 7 days
• No systemic chemotherapy
• Patients with voluntary participation, and sign the informed consent