Anatomical Resection of Liver MetAstases iN patIents With RAS-mutated Colorectal Cancer
Status: Recruiting
Location: See all (37) locations...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
the ARMANI trial will test the hypothesis, if an anatomic resection (AR) improves long-term outcome vs. a non-anatomical resection (NAR) in patients undergoing surgery for RAS-mutated colorectal liver metastasis (CRLM).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Colorectal cancer with RAS mutation (KRAS or NRAS)
• Colorectal liver metastases (single or multiple)
• Planned R0 resection of liver metastases (and primary tumor, if present)
• Anatomical and non-anatomical liver resection technically feasible
• Male and female patients, age ≥ 18 years
• Written informed consent
Locations
Other Locations
Germany
Intestinal Center West Middle Franconia, ANregiomed Clinic Ansbach
RECRUITING
Ansbach
Clinic for General, Vizeral and Transplant Surgery, Augsburg University Hospital
RECRUITING
Augsburg
Department of General, Visceral and Vascular Surgery, Charité, University Medicine Berlin, Campus Benjamin Franklin Berlin
RECRUITING
Berlin
Clinic and Polyclinic for General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn
RECRUITING
Bonn
Surgical Clinic, Municipal Hospital Braunschweig gGmbH
RECRUITING
Braunschweig
Cancer Center, Helios Amper-Hospital Dachau
RECRUITING
Dachau
Surgical Clinic, Dortmund Hospital
RECRUITING
Dortmund
Clinic for General and Visceral Surgery, Municipal Hospital Dresden
RECRUITING
Dresden
Department of Gastrointestinal-, Thoracic and Vascular Surgery University Hospital Carl Gustav Carus Technische Universität Dresden
RECRUITING
Dresden
Clinic for General, Visceral and Pediatric Surgery, University Hospital Düsseldorf
RECRUITING
Düsseldorf
Surgical Clinic, University Hospital Erlangen
RECRUITING
Erlangen
Clinic for General, Visceral and Transplant Surgery, University Hospital Frankfurt, Goethe University Frankfurt am Main
RECRUITING
Frankfurt
Department for General and Visceral Surgery, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg
RECRUITING
Freiburg Im Breisgau
JLU Gießen, Department for General, Visceral, Thoracic and Transplant Surgery
RECRUITING
Giessen
Clinic for General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Georg-August-University
RECRUITING
Göttingen
Clinic and Polyclinic for General Surgery, Department of Gastrointestinal, Thoracic and Vascular Surgery, University Greifswald, University Hospital Greifswald
RECRUITING
Greifswald
University Hospital and Polyclinic for Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale)
RECRUITING
Halle
Center for Surgical Medicine - Clinic and Polyclinic for General, Visceral and Thoracic Surgery, University Hospital Hamburg-Eppendorf
RECRUITING
Hamburg
Department of Liver, Bile Duct and Pancreas Surgery, University Department of surgery, Asklepios Klinik Barmbek
RECRUITING
Hamburg
Clinic for General, Visceral and Minimally Invasive Surgery, KRH Clinic Siloah, Hannover
RECRUITING
Hanover
Medizinische Hochschule Hannover, Department of General, Visceral and Transplant Surgery
RECRUITING
Hanover
Department of General, Visceral and Transplantation Surgery, University of Heidelberg
RECRUITING
Heidelberg
General Visceral and Vascular Surgery, Jena University Medical Center
RECRUITING
Jena
Clinic for Surgery, University Hospital Schleswig-Holstein Lübeck Campus
RECRUITING
Lübeck
University Department of General, Visceral, Vascular and Transplant Surgery, Faculty of Medicine, Otto von Guericke University Magdeburg
RECRUITING
Magdeburg
Clinic for General, Visceral and Transplantation Surgery, University Medical Center of the Johannes Gutenberg-University Mainz
RECRUITING
Mainz
Department of Surgery at the University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University
RECRUITING
Mannheim
Clinic for Visceral, Thoracic and Vascular Surgery, University Hospital Giessen and Marburg
RECRUITING
Marburg
Department Hepato-Pancreato-Biliary Surgery, Barmherzige Brüder gGmbH of the Hospital Barmherzige Brüder Munich
RECRUITING
München
Department of Surgery, University Hospital rechts der Isar
RECRUITING
München
LMU Munich Hospital, Clinic for General, Visceral and Transplant Surgery
RECRUITING
Munich
Clinic for General, Visceral and Transplant Surgery, University of Münster
RECRUITING
Münster
University Hospital for General and Visceral Surgery, Oldenburg Hospital
WITHDRAWN
Oldenburg
Department of General, Visceral and Transplant Surgery, University of Tübingen, Comprehensive Cancer Center
RECRUITING
Tübingen
Clinic for General and Visceral Surgery, Ulm University Medical Center
RECRUITING
Ulm
General and Visceral Surgery, Helios University Medical Center Wuppertal, University Witten/Herdecke
RECRUITING
Wuppertal
Department for General, Visceral, Transplant, Vascular and Pediatric Surgery, Julius-Maximilian-University Würzburg, University Hospital Würzburg
RECRUITING
Würzburg
Contact Information
Primary
Jürgen Weitz, Prof Dr med
juergen.weitz@ukdd.de
+49-(0)351 458 4850
Time Frame
Start Date: 2021-01-01
Estimated Completion Date: 2027-12
Participants
Target number of participants: 240
Treatments
Experimental: A - Anatomical resection
removal of the entire, tumor-bearing liver segment(s)
Active_comparator: B - Non-anatomical resection
metastasectomy with a margin of healthy liver tissue irrespective of segmental borders
Authors
Related Therapeutic Areas
Sponsors
Leads: Technische Universität Dresden
Collaborators: German Cancer Research Center