VIVA: Volatile or IV Anesthesia for Cancer

Status: Recruiting
Location: See location...
Intervention Type: Other, Drug, Procedure
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

This trial evaluates how inhalational anesthesia (drawn in through the lungs) and total intravenous anesthesia (TIVA) (through a needle in a vein in the arm) change the body's ability to recover from surgery or whether they impact the immune system immediately after surgery in patients with colon cancer. It is unknown whether these types of anesthesia change recovery from surgery or change the chances cancer comes back following surgery. This study may help researchers learn how different types of anesthesia affect recovery from colon cancer surgery.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
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• Ability of participant OR Legally Authorized Representative (LAR) to understand this study, and participant or LAR willingness to sign a written informed consent

• Males and females age \>= 18 years on day of consent

• Eastern Cooperative Oncology Group (ECOG) performance status 0 - 2

• Patients undergoing resection for biopsy proven colon adenocarcinoma

• Medically fit for colon resection

• Ability to complete required study questionnaires

• Stated willingness to comply with all study procedures and availability for the duration of the study

Locations
United States
Kansas
University of Kansas Cancer Center
RECRUITING
Kansas City
Time Frame
Start Date: 2023-05-22
Estimated Completion Date: 2026-05-22
Participants
Target number of participants: 80
Treatments
Active_comparator: Arm I (sevoflurane, fentanyl citrate, propofol)
Patients receive SOC sedation with sevoflurane via inhalation and fentanyl IV on study during to SOC surgery. All patients also undergo blood sample collection throughout the study and collection of tissue sample during surgery.
Experimental: Arm II (fentanyl citrate, propofol)
Patients receive SOC sedation with fentanyl IV and propofol IV on study during to SOC surgery. Patients also undergo blood sample collection throughout the study and collection of tissue sample during surgery.
Related Therapeutic Areas
Sponsors
Leads: University of Kansas Medical Center
Collaborators: National Cancer Institute (NCI)

This content was sourced from clinicaltrials.gov