Neoadjuvant Preoperative Arterial Intervention With Concurrent Chemoradiotherapy in Local Advanced Rectal Cancer
To increase the efficacy of neoadjuvant PD-1/PD-1 checkpoint inhibitor in local advanced rectal cancer (LARC), we propose preoperative arterial infusion of Tirellizumab and oxaliplatin followed by tumor artery embolization with concurrent chemoradiotherapy as neoadjuvant regimen for LARC.
• Local advanced Rectal cancer: stage T3/4NanyM0 or T1-2N+M0.
• Ages: 18 to 75.
• No previously received chemotherapy drugs and radiation therapy.
• ECOG score: 0 - 2.
• Appropriate organ function, as defined below:
⁃ (Hematology and blood biochemistry examination must be completed within 7 days before the registration date) i) White blood cell count ≥ 4,000/mm3. ii) Neutrophil count ≥ 1,500/mm3. iii) Hemoglobin ≥ 10 g/dL. iv) Platelet count ≥ 100,000/mm3. v) Total bilirubin ≤ 1.5 times the upper limit of normal (ULN). vi. Liver function Index (AST \& ALT) ≤ 1.5 times the upper limit of normal (ULN).
⁃ vii. Serum creatinine ≤1.5 times the upper limit of normal or creatinine clearance ≥60 ml/min.
• Tolerance of orally administration of capecitabine.
• Can understand the study, have good compliance, cooperate with follow-up.