A Randomized, Double-Blind, Phase 3 Study of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
Status: Recruiting
Location: See all (197) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The purpose of this study is to evaluate the efficacy and safety of standard-of-care chemotherapy and bevacizumab with or without INCA33890 in the first-line treatment of metastatic microsatellite stable colorectal cancer.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Stage IV colorectal adenocarcinoma not amenable to curative resection.
• No prior systemic treatment for unresectable or metastatic disease. Participants who received adjuvant or neoadjuvant therapy may enroll if there was no recurrence within 12 months of the end of treatment.
• Measurable disease per RECIST v1.1.
• ECOG performance status of 0 or 1.
• Adequate organ function determined by laboratory results.
Locations
United States
Arizona
Ironwood Cancer & Research Centers
NOT_YET_RECRUITING
Chandler
The University of Arizona Cancer Center
NOT_YET_RECRUITING
Tucson
California
Providence Medical Foundation
NOT_YET_RECRUITING
Fullerton
University of California Los Angeles Health
NOT_YET_RECRUITING
Los Angeles
Connecticut
Hartford Hospital
NOT_YET_RECRUITING
Hartford
Florida
University of Florida Health
NOT_YET_RECRUITING
Gainesville
Sylvester Comprehensive Cancer Center
NOT_YET_RECRUITING
Miami
Advent Health
NOT_YET_RECRUITING
Orlando
Orlando Health Cancer Institute Downtown Orlando
NOT_YET_RECRUITING
Orlando
Ascension Sacred Heart Pensacola
NOT_YET_RECRUITING
Pensacola
Idaho
St Lukes Mountain States Tumor Institute Msti Boise
NOT_YET_RECRUITING
Boise
Illinois
Endeavor Health
NOT_YET_RECRUITING
Evanston
Springfield Clinic
NOT_YET_RECRUITING
Springfield
Indiana
Community Health Network
NOT_YET_RECRUITING
Indianapolis
Maryland
Saint Agnes Hospital
NOT_YET_RECRUITING
Baltimore
Cancer Center For Blood Disorders A Division of American Oncology Partners P.A
NOT_YET_RECRUITING
Bethesda
Michigan
St. Joseph Mercy Hospital
NOT_YET_RECRUITING
Ann Arbor
University of Michigan
NOT_YET_RECRUITING
Ann Arbor
Henry Ford Hospital
NOT_YET_RECRUITING
Detroit
Missouri
Midamerica Cancer Care
NOT_YET_RECRUITING
Kansas City
Saint Luke'S Hospital of Kansas City
NOT_YET_RECRUITING
Kansas City
Oncology Hematology Associates
NOT_YET_RECRUITING
Springfield
Washington University School of Medicine
NOT_YET_RECRUITING
St Louis
North Carolina
Messino Cancer Center
NOT_YET_RECRUITING
Asheville
The University of North Carolina At Chapel Hill
NOT_YET_RECRUITING
Chapel Hill
Oncology Specialists of Charlotte
NOT_YET_RECRUITING
Charlotte
New Jersey
Morristown Medical Center
NOT_YET_RECRUITING
Morristown
New York
Icahn School of Medicine At Mount Sinai
NOT_YET_RECRUITING
New York
Memorial Sloan Kettering Cancer Center
NOT_YET_RECRUITING
New York
Ny Cancer and Blood Specialists
NOT_YET_RECRUITING
Patchogue
University of Rochester
NOT_YET_RECRUITING
Rochester
Montefiore Einstein For Cancer Care
NOT_YET_RECRUITING
The Bronx
Ohio
University of Cincinnati Cancer Institute
NOT_YET_RECRUITING
Cincinnati
Ohio State University-Arthur G James Comprehensive Cancer Center
NOT_YET_RECRUITING
Columbus
Pennsylvania
Penn State Milton S. Hershey Medical Center
NOT_YET_RECRUITING
Hershey
University of Pennsylvania
NOT_YET_RECRUITING
Philadelphia
Allegheny General Hospital Cancer Institute
NOT_YET_RECRUITING
Pittsburgh
University of Pittsburgh Medical Center Upmc Hillman Cancer Center
NOT_YET_RECRUITING
Pittsburgh
Cancer Care Associates of York
NOT_YET_RECRUITING
York
South Dakota
Avera Cancer Institute
NOT_YET_RECRUITING
Sioux Falls
Tennessee
Provision Center For Biomedical Research
NOT_YET_RECRUITING
Knoxville
Sarah Cannon Research Institute Scri Oncology Partners
NOT_YET_RECRUITING
Nashville
Texas
Shivers Cancer Center
NOT_YET_RECRUITING
Austin
Texas Oncology
NOT_YET_RECRUITING
Austin
University of Texas Southwestern Medical Center
NOT_YET_RECRUITING
Dallas
Md Anderson Cancer Center
NOT_YET_RECRUITING
Houston
Virginia
Shenandoah Oncology
NOT_YET_RECRUITING
Winchester
West Virginia
Vandalia Health Charleston Area Medical Center
NOT_YET_RECRUITING
Charleston
West Virginia University
NOT_YET_RECRUITING
Morgantown
Other Locations
Argentina
Hospital Britanico de Buenos Aires
NOT_YET_RECRUITING
Buenos Aires
Instituto Medico Especializado Alexander Fleming
NOT_YET_RECRUITING
Buenos Aires
Investigaciones Clinicas Moleculares Icm
NOT_YET_RECRUITING
Buenos Aires
Hospital Italiano de Buenos Aires
NOT_YET_RECRUITING
Ciudad Autonoma Buenos Aires
Hospital Privado Centro Medico de Cordoba S.A
NOT_YET_RECRUITING
Córdoba
Instituto de Investigaciones Clinicas Cordoba S.A.
NOT_YET_RECRUITING
Córdoba
Centro Oncologico Riojano Integral (Cori)
NOT_YET_RECRUITING
La Rioja
Investigaciones Oncologicas C Colon
NOT_YET_RECRUITING
Mar Del Plata
Instituto de Oncologia de Rosario
NOT_YET_RECRUITING
Rosario
Exelsus Srl
NOT_YET_RECRUITING
San Miguel De Tucumán
Australia
Border Cancer Hospital Dispensary - Albury Wodonga Regional Cancer Centre
NOT_YET_RECRUITING
Albury
Box Hill Hospital
NOT_YET_RECRUITING
Box Hill
Austin Hospital
NOT_YET_RECRUITING
Heidelberg
Peter Maccallum Cancer Centre
NOT_YET_RECRUITING
Melbourne
The Alfred Hospital
NOT_YET_RECRUITING
Melbourne
Fiona Stanley Hospital
NOT_YET_RECRUITING
Murdoch
Port Macquarie Base Hospital
NOT_YET_RECRUITING
Port Macquarie
Prince of Wales Hospital Au
NOT_YET_RECRUITING
Randwick
Townsville Cancer Centre
NOT_YET_RECRUITING
Townsville
Calvary Mater Newcastle
NOT_YET_RECRUITING
Waratah
Westmead Hospital
NOT_YET_RECRUITING
Westmead
Wollongong Hospital
NOT_YET_RECRUITING
Wollongong
Princess Alexandra Hospital Australia
NOT_YET_RECRUITING
Woolloongabba
Austria
Lkh - Universitaetsklinikum Graz
NOT_YET_RECRUITING
Graz
Ordensklinikum Krankenhaus Der Barmherzigen Schwestern Linz
NOT_YET_RECRUITING
Linz
Lkh - Universitatsklinikum Der Pmu Salzburg
NOT_YET_RECRUITING
Salzburg
Akh - Medizinische Universität Wien
NOT_YET_RECRUITING
Vienna
Belgium
Cliniques Universitaires Ucl Saint-Luc
NOT_YET_RECRUITING
Brussels
Universitair Ziekenhuis Brussel
NOT_YET_RECRUITING
Brussels
Universitair Ziekenhuis Antwerpen (Uza)
NOT_YET_RECRUITING
Edegem
Universitair Ziekenhuis Gent (Uz Gent)
NOT_YET_RECRUITING
Ghent
Universitaire Ziekenhuis Leuven - Gasthuisberg
NOT_YET_RECRUITING
Leuven
Chu Ucl Namur University Hospital Mont-Godinne
NOT_YET_RECRUITING
Yvoir
Brazil
Fundacao Pio Xii Hospital de Cancer de Barretos
NOT_YET_RECRUITING
Barretos
Centro de Pesquisas Clinica Reichow
NOT_YET_RECRUITING
Blumenau
Oncosite - Centro de Pesquisa Clinica E Oncologia
NOT_YET_RECRUITING
Ijuí
Clinica de Neoplasias Litoral Ltda
NOT_YET_RECRUITING
Itajaí
Liga Norte-Rio-Grandense Contra O Câncer
NOT_YET_RECRUITING
Natal
Centro Gaucho Integrado de Oncologia, Hematologia, Ensino E Pesquisa - Hospital Mae de Deus
NOT_YET_RECRUITING
Porto Alegre
Hospital de Clinicas de Porto Alegre
NOT_YET_RECRUITING
Porto Alegre
Irmandade Da Santa Casa de Misericordia de Porto Alegre
NOT_YET_RECRUITING
Porto Alegre
Hospital Das Clínicas Fmrp-Usp
NOT_YET_RECRUITING
Ribeirão Preto
Nob - Nucleo de Oncologia Da Bahia
NOT_YET_RECRUITING
Salvador
Cepho - Centro de Estudos E Pesquisas de Hematologia E Oncologia
NOT_YET_RECRUITING
Santo André
Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto
NOT_YET_RECRUITING
Sao Jose Rio Preto
Icavc - Instituto Do Câncer Arnaldo Vieira de Carvalho
NOT_YET_RECRUITING
São Paulo
Canada
Cross Cancer Institute
NOT_YET_RECRUITING
Edmonton
Hôtel-Dieu de Lévis
NOT_YET_RECRUITING
Lévis
McGill University Health Centre Research Institute
NOT_YET_RECRUITING
Montreal
Southlake Regional Health Center
NOT_YET_RECRUITING
Newmarket
Princess Margaret Cancer Center
NOT_YET_RECRUITING
Toronto
Denmark
Aalborg Universitetshospital
NOT_YET_RECRUITING
Aalborg
OUH
NOT_YET_RECRUITING
Odense C
Sjaellands Universitetshospital
NOT_YET_RECRUITING
Roskilde
Sygehus Lillebælt - Vejle
NOT_YET_RECRUITING
Vejle
France
Chu Bordeaux-Hopital Pellegrin
NOT_YET_RECRUITING
Bordeaux
Hôpital de La Timone
NOT_YET_RECRUITING
Marseille
Institut Paoli Calmettes
NOT_YET_RECRUITING
Marseille
Hôpital Européen Georges Pompidou
NOT_YET_RECRUITING
Paris
Hospital Universitaire Pitie-Salpetriere
NOT_YET_RECRUITING
Paris
Hospital de La Miletrie
NOT_YET_RECRUITING
Poitiers
Chu de Reims
NOT_YET_RECRUITING
Reims
University Hospital of Saint Etienne
NOT_YET_RECRUITING
Saint-etienne
Chu Toulouse Hopital Rangueil
NOT_YET_RECRUITING
Toulouse
Institut Gustave Roussy
NOT_YET_RECRUITING
Villejuif
Germany
Charite - Campus Virchow-Klinikum
NOT_YET_RECRUITING
Berlin
University Hospital Carl Gustav Carus
NOT_YET_RECRUITING
Dresden
Universitaetsklinikum Essen
NOT_YET_RECRUITING
Essen
Krankenhaus Nordwest Gmbh
NOT_YET_RECRUITING
Frankfurt Am Main
University Medical Center Freiburg
NOT_YET_RECRUITING
Freiburg Im Breisgau
Asklepios Tumorzentrum Hamburg
NOT_YET_RECRUITING
Hamburg
University Medical Centre Hamburg-Eppendorf Centre of Oncology
NOT_YET_RECRUITING
Hamburg
Hannover Medical School
NOT_YET_RECRUITING
Hanover
Uksh Campus Lubeck
NOT_YET_RECRUITING
Lübeck
Klinikum Der University Munchen - Campus Grosshadern
NOT_YET_RECRUITING
München
Klinikum Neuperlach
NOT_YET_RECRUITING
München
Universitaetsklinikum Regensburg
NOT_YET_RECRUITING
Regensburg
Universitatkinikums Ulm
NOT_YET_RECRUITING
Ulm
Italy
Azienda Ospedaliero Universitaria Delle Marche
NOT_YET_RECRUITING
Ancona
Irccs Centro Di Riferimento Oncologico
NOT_YET_RECRUITING
Aviano
Istituto Tumori Giovanni Paolo Ii Irccs Ospedale Oncologico Bari
NOT_YET_RECRUITING
Bari
Fondazione Poliambulanza Istituto Ospedaliero
NOT_YET_RECRUITING
Brescia
Istituto Di Candiolo Fondazione Del Piemonte Per L'Oncologia - Irccs
NOT_YET_RECRUITING
Candiolo
Asst Grande Ospedale Metropolitano Niguarda
NOT_YET_RECRUITING
Milan
Comitato Etico Fondazione Irccs Istituto Nazionale Dei Tumori Milano
NOT_YET_RECRUITING
Milan
Azienda Ospedaliera Universitaria- Università Degli Studi Della Campania Luigi Vanvitelli
NOT_YET_RECRUITING
Napoli
Iov - Istituto Oncologico Veneto Irccs
NOT_YET_RECRUITING
Padua
Azienda Ospedaliero Universitaria Pisana
NOT_YET_RECRUITING
Pisa
Ospedale Santa Maria Delle Croci
NOT_YET_RECRUITING
Ravenna
Arcispedale S. Maria Nuova Azienda Ospedaliera Di Reggio Emilia
NOT_YET_RECRUITING
Reggio Emilia
Azienda Ospedaliera San Camillo Forlanini
NOT_YET_RECRUITING
Roma
Irccs Istituto Clinico Humanitas
NOT_YET_RECRUITING
Rozzano
I.R.C.C.S. Casa Sollievo Della Sofferenza
NOT_YET_RECRUITING
San Giovanni Rotondo
Centro Ricerche Cliniche Di Verona
NOT_YET_RECRUITING
Verona
Japan
Chiba Cancer Center
NOT_YET_RECRUITING
Chiba
National Cancer Center Hospital
NOT_YET_RECRUITING
Chūōku
Nho Kyushu Cancer Center
NOT_YET_RECRUITING
Fukuoka
Saitama Medical University International Medical Center
NOT_YET_RECRUITING
Hidaka-shi
National Cancer Center Hospital East
NOT_YET_RECRUITING
Kashiwa-shi
Cancer Institute Hospital of Jfcr
NOT_YET_RECRUITING
Kōtoku
Nho Shikoku Cancer Center
NOT_YET_RECRUITING
Matsuyama
Osaka International Cancer Institute
NOT_YET_RECRUITING
Osaka
The University of Osaka Hospital
NOT_YET_RECRUITING
Suita-shi
Shizuoka Cancer Center
NOT_YET_RECRUITING
Sunto-gun
Kanagawa Cancer Center
NOT_YET_RECRUITING
Yokohama
Netherlands
Meander Medisch Centrum
NOT_YET_RECRUITING
Amersfoort
Martini Ziekenhuis
NOT_YET_RECRUITING
Groningen
Maastricht Umc+
NOT_YET_RECRUITING
Maastricht
Erasmus Medical Center
NOT_YET_RECRUITING
Rotterdam
Norway
Haukeland Universitetssjukehus
NOT_YET_RECRUITING
Bergen
Akershus Universitetssykehus Hf
NOT_YET_RECRUITING
Lørenskog
Oslo Universitetssykehus
NOT_YET_RECRUITING
Oslo
Poland
Wojewodzkie Centrum Szpitalne Kotliny Jeleniogorskiej
NOT_YET_RECRUITING
Jelenia Góra
Mazowiecki Szpital Wojewodzki Im. SW. Jana Pawla Ii W Siedlcach Sp Z O O
NOT_YET_RECRUITING
Siedlce
Luxmed Onkologia Sp. Z O.O.
NOT_YET_RECRUITING
Warsaw
Narodowy Instytut Onkologii Im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy
NOT_YET_RECRUITING
Warsaw
Puerto Rico
Pan American Center For Oncology Trials Llc Dorado Office
RECRUITING
Dorado
Republic of Korea
Seoul National University Bundang Hospital
NOT_YET_RECRUITING
Seongnam
Korea University Anam Hospital
NOT_YET_RECRUITING
Seoul
Seoul National University Hospital
NOT_YET_RECRUITING
Seoul
Severance Hospital Yonsei University Health System
NOT_YET_RECRUITING
Seoul
The Catholic University of Korea Seoul St. Mary'S Hospital
NOT_YET_RECRUITING
Seoul
Spain
Hospital Universitari Germans Trias I Pujol
NOT_YET_RECRUITING
Badalona
Hospital Clinic Barcelona Main
NOT_YET_RECRUITING
Barcelona
Hospital de La Santa Creu I Sant Pau
NOT_YET_RECRUITING
Barcelona
Hospital General Universitario Vall D Hebron
NOT_YET_RECRUITING
Barcelona
Complejo Hospitalario Universitario Insular-Materno Infantil
NOT_YET_RECRUITING
Las Palmas De Gran Canaria
Hospital General Universitario Gregorio Maranon
NOT_YET_RECRUITING
Madrid
Hospital Universitario 12 de Octubre
NOT_YET_RECRUITING
Madrid
Hospital Universitario Fundacion Jimenez Diaz
NOT_YET_RECRUITING
Madrid
Hospital Universitario Puerta de Hierro de Majadahonda
NOT_YET_RECRUITING
Majadahonda
Son Espases University Hospital
NOT_YET_RECRUITING
Palma De Mallorca
Hospital Universitario de Navarra
NOT_YET_RECRUITING
Pamplona
Hospital Universitario Marques de Valdecilla
NOT_YET_RECRUITING
Santander
Hospital Universitari Mutua de Terrassa
NOT_YET_RECRUITING
Terrassa
Hospital Clinico Universitario de Valencia
NOT_YET_RECRUITING
Valencia
Hospital Universitario Miguel Servet
NOT_YET_RECRUITING
Zaragoza
Switzerland
Inselspital - Universitaetsspital Bern
NOT_YET_RECRUITING
Bern
Chuv, Lausanne University Hospital
NOT_YET_RECRUITING
Lausanne
Hoch Health Ostschweiz
NOT_YET_RECRUITING
Sankt Gallen
United Kingdom
Bristol Haematology and Oncology Centre
NOT_YET_RECRUITING
Bristol
Velindre Cancer Centre
NOT_YET_RECRUITING
Cardiff
St James University Hospital
NOT_YET_RECRUITING
Leeds
Barts Hospital
NOT_YET_RECRUITING
London
Guys Hospital
NOT_YET_RECRUITING
London
Kent Oncology Centre - Maidstone Hospital
NOT_YET_RECRUITING
Maidstone
The Christie Nhs Foundation Trust Uk
NOT_YET_RECRUITING
Manchester
The Royal Marsden Nhs Foundation Trust - Chelsea
NOT_YET_RECRUITING
Sutton
Contact Information
Primary
Incyte Corporation Call Center (US)
medinfo@incyte.com
1.855.463.3463
Backup
Incyte Corporation Call Center (ex-US)
eumedinfo@incyte.com
+800 00027423
Time Frame
Start Date: 2026-02-16
Estimated Completion Date: 2029-09-28
Participants
Target number of participants: 700
Treatments
Experimental: INCA33890
INCA33890 will be administered in combination with bevacizumab and FOLFOX at the protocol-defined dose.
Placebo_comparator: Placebo
Placebo will be administered in combination with bevacizumab and FOLFOX at the protocol-defined dose.
Related Therapeutic Areas
Sponsors
Leads: Incyte Corporation