The Impact of Neoadjuvant Therapy on Perioperative Complications and Treatment Outcomes in Patients Undergoing Colorectal Cancer Resection
This prospective study investigates the effects of neoadjuvant therapy on endothelial function, microvascular tissue density, and tissue fibrosis in patients with colorectal cancer and their association with perioperative complications. The primary objective is to assess differences in microvascular tissue density between patients who received neoadjuvant therapy and those who did not, biomarkers, and demographic factors between patients who received neoadjuvant therapy and those who underwent surgery as initial treatment, and to compare clinical outcomes. The study will include 34 patients treated with neoadjuvant therapy and 34 patients for whom surgery is the first-line treatment. Patients will be followed until discharge from the hospital, and complications after discharge will be monitored through medical records one month after surgery.
• Adults aged ≥18 years with histologically confirmed colorectal cancer
• Planned surgical treatment for colorectal cancer (either laparoscopic LPSC or open laparotomy)
• Ability to understand the study protocol and provide written informed consent.
• Both sexes
• ASA classification II or III
• Patients who received neoadjuvant therapy is investigational group and patients who did not receive neoadjuvant therapy is control group