• Age: 18-70 years old

• Histologically confirmed colorectal adenocarcinoma

• Radiologically or pathologically confirmed diagnosis of colorectal liver metastasis

• Initially unresectable colorectal liver metastasis confirmed by the multidisciplinary team (MDT)

• With no prior treatment for liver metastasis, including chemotherapy, operation, radiotherapy, transcatheter hepatic arterial chemoembolization (TACE) and targeted therapy

• Without extra-hepatic metastasis confirmed by CT, MRI or PET/CT (if necessary) scanning

• With adequate bone marrow function: platelets ≥ 90 x 109/L; white blood cells ≥ 3×109/L; absolute neutrophil count (ANC) ≥ 1.5 x 109/L

• Serum bilirubin ≤ 1.5 x ULN, AST and ALT ≤ 5 x ULN

• Patient has no ascites and with adequate blood coagulation function, albumin ≥ 35 g/L

• Grade A level of Child-Push Liver Function

• Creatinine ≤ 1× ULN, or Calculated Creatinine Clearance \>50ml/min （Cockcroft-Gault Equation）

• ECOG performance status of 0-2

• Life expectancy ≥ 3 months

• Not appropriate for anti-EGFR or any other targeted therapy (with KRAS mutation or could not afford it)

• Patients have provided a signed Informed Consent Form

• With good compliance