Development and Validation of Microbiota and Metabolite-based Prediction Model for Recurrence of High-risk Colorectal Polyps After Polypectomy
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
The characteristics of the intestinal microbiota in high-risk colorectal polyp recurrence and their relationship with disease pathogenesis have not yet been fully elucidated. This study aims to analyze the microbial community characteristics in the intestinal mucosal tissue of patients after polypectomy with recurrence of colorectal polyps. Additionally, this research holds significant importance for understanding the etiology of adenoma recurrence and develop a microbiota and metabolite-based predicting tool.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 75
Healthy Volunteers: f
View:
• patients aged 40-75 years who undergo the colonoscopy with at least 1 advanced premalignant polyps or ≥ 3 adenoma
Locations
Other Locations
China
Peking Union Medical College Hospital, 1 Shuaifuyuan, Dongcheng District, Beijing, China
RECRUITING
Beijing
Contact Information
Primary
Cheng Peng, MD
pengchengf@mail.sdu.edu.cn
+86 18500743525
Time Frame
Start Date: 2023-04-25
Estimated Completion Date: 2026-04-30
Participants
Target number of participants: 150
Treatments
Patients who undergo colonoscopy with precence of high-risk colorectal polyps
For patients who undergo colonoscopy with presence of high-risk colorectal polyps, collect 1-2 pieces of large intestinal mucosa of the polyp and the normal appearing mucosa surrounding the polyp. Collect stool samples and baseline information such as age, gender and eating habit.~Each patient will be followed for 3 years, and colonoscopy will be reviewed to determine the recurrence. Biopsies of large intestinal mucosa and stools will be collected at surveillance colonoscopy (follow-up) if allowed. All the samples are stored at -80°C by the study team until the time of DNA extraction for microbiota sequencing analysis and/or metabolomic analysis.
Related Therapeutic Areas
Sponsors
Leads: Peking Union Medical College Hospital