Blood Biomarkers to Improve Management of Mild Traumatic BRAIN Injury in the Elderly
Mild traumatic brain injury (mTBI) is one of the most frequent emergencies in the elderly population. Despite most mTBI are managed with cranial computed tomography (CT), only 10% of CTs show lesions, determining CT overuse. The use of serum glial fibrillary acidic protein (GFAP) and Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) have shown potential for ruling out the need for cranial CT. However evidence on biomarker use in mild TBI were not based on studies that included aged participants and patients with comorbidities for which biomarker levels could vary. This is why there is a need for a prospective study that assesses the predictive performance of these two biomarkers in the elderly population, both in elderly patients suffering mild TBI and in a reference population, including patients and participants with and without comorbidities.
• BRAINI2-ELDERLY DIAGNOSTIC \& PROGNOSTIC:
‣ Patients ≥65 years of age
⁃ Mild TBI (GCS 13-15 on admission) with indication of brain CT scan in the 12 hours after injury ;
⁃ Blood sample obtained ≤12 h after injury and CT scan preferably ≤6h from blood sample.
• BRAINI2-ELDERLY REFERENCE:
‣ Non TBI patients ≥65 years of age