Post-Concussion Syndrome in Professional Athletes: A Multidisciplinary Study

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

to examine the relationship between repeated concussions and late decline of brain function. In addition, all participants agreeing to participate in the study will be asked to will their brains to The Krembil Neuroscience Centre Concussion Project at the Toronto Western Hospital with the consent and full knowledge of their families and doctors. However, it is possible to participate in the research without agreeing to a brain donation. The Project Team is specifically attempting a clinical-MRI-brain tissue research analysis to determine the exact mechanism of the damage to brain tissue following repeated concussions. This condition is known as chronic traumatic encephalopathy (CTE), and shows an abnormal protein in the brain called tau-protein.

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 25
Maximum Age: 85
Healthy Volunteers: t
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• fluent in English, and a history of multiple concussions , low exposures , or no concussions (Control group ). Determination of concussion exposure will be determined as follows: Previous concussion will be based on the player's recall of injury and defined as an injury resulting from a blow to the head that caused an alteration in mental status and one or more of the following symptoms: headache, nausea, vomiting, dizziness/balance problems, fatigue, trouble sleeping, drowsiness, sensitivity to light or noise, blurred vision, difficulty remembering, and difficulty concentrating.

Locations
Other Locations
Canada
Canadian Concussion Centre, Toronto Western Hospital, University Health Network
RECRUITING
Toronto
Contact Information
Primary
Mozhgan Khodadadi, MA
Mozhgan.Khodadadi@uhn.ca
416-603-5800
Time Frame
Start Date: 2011-07-04
Estimated Completion Date: 2030-12-30
Participants
Target number of participants: 150
Treatments
Former concussed pro-athletes
Biomarkers for detecting possible CTE invivo in former pro-athletes with multiple concussions: Imaging/blood/cerebrospinal fluid (CSF)/Positron emission tomography (PET-)tau/magnetic resonance imaging (MRI)/neuropsychological assessment.
Healthy controls
Active Comparator
Related Therapeutic Areas
Sponsors
Collaborators: The Weston A. Price Foundation
Leads: University Health Network, Toronto

This content was sourced from clinicaltrials.gov

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