A Clinical Study of Fundus Optical Coherence Tomography Angiography for the Identification of Coronary Microvascular Diseases

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

Coronary microvascular dysfunction (CMD) carries an increased risk of adverse cardiovascular clinical outcomes. The association between fundus microcirculation changes and coronary microcirculation is not well understood. Optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) is a new type of optical diagnostic imaging technology for non-invasive detection, which can perform multi-dimensional quantitative assessment of fundus microcirculation. In this study, investigators intend to use the coronary angiography-derived index of microvascular resistance (caIMR) to screen patients with CMD, explore the relationship between relevant parameters based on OCT and OCTA measurements and caIMR, and evaluate the feasibility and clinical value of non-invasive identification of CMD through fundus OCT and OCTA.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients who underwent coronary angiography in the Department of Cardiology, Peking University First Hospital;

• Complete baseline clinical information;

• Subject who have coronary angiography results, which shows coronary stenosis \< 50%;

• Older than 18 years;

• Subjects who have signed informed consent.

Locations
Other Locations
China
Peking university first hospital
RECRUITING
Beijing
Contact Information
Primary
Bo Zheng, Dr
zhengbopatrick@163.com
13426046980
Time Frame
Start Date: 2023-03-01
Estimated Completion Date: 2026-01-01
Participants
Target number of participants: 400
Treatments
CMD group, Non-CMD group
CMD group: participants whose CaIMR shows ≥25U. Non-CMD group: participants whose CaIMR less than 25U.
Related Therapeutic Areas
Sponsors
Leads: Peking University First Hospital

This content was sourced from clinicaltrials.gov