Investigating Blood Lipid Responses to Dietary Macronutrient Content
The macronutrient composition of our diet (proportions of carbohydrates, fats and proteins) strongly influences the way our body stores and utilises substrates (e.g., fats and sugars), which in turn influences our risk of developing cardiometabolic diseases (e.g., coronary artery disease or insulin resistance). The optimal dietary composition to lower the risk of cardiometabolic disease is unknown. In a randomized, parallel design, this study will investigate how the overconsumption of carbohydrates and fats affects blood lipid responses and liver metabolism in adults free from metabolic disease. By genotyping participants, we will also examine the interaction between macronutrient content and an individual's genes on blood lipid responses and liver metabolism.
• Participant is willing and able to give informed consent for participation in the study.
• Male or Female, aged ≥18 to ≤65 years
• Body mass index (BMI) ≥19 to ≤35 kg/m2
• No medical condition or relevant drug therapy that is known to affect the liver, adipose tissue, or cardiac metabolism.
• Weight stable for the previous 3 months