Multimodality Imaging and Functional Lesion Assessment in Intermediate Grade Coronary Stenosis in Chronic Coronary Syndrome: MultiInter-CCS Study

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The aim of this prospective, investigator-initiated study is to evaluate the diagnostic accuracy and correlations between functional indices (fractional flow reserve, FFR) and morphometric indices: luminal and qualitative parameters assessed by optical coherence tomography (OCT) including minimal lumen area, plaque type, presence of thin cap fibroatheroma among patients with chronic coronary syndrome identified with intermediate grade coronary stenosis.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• 18 years or older

• Chronic coronary syndrome defined as presence of chest pain ranked 2-3 in the Canadian Cardiovascular Society classification or positive ischemia test (exercise test, single photon emission tomography (SPECT)

• Intermediate grade coronary stenosis of 40-80% assessed visually in coronary angiography

• FFR and OCT examination of the same lesion

• The patient is willing to participate in the study and has provided a written informed consent

Locations
Other Locations
Poland
Medical University of Warsaw
RECRUITING
Warsaw
Contact Information
Primary
Mariusz Tomaniak
mariusz.tomaniak@wum.edu.pl
Backup
Piotr Baruś
piotr.barus@wum.edu.pl
Time Frame
Start Date: 2011-04-07
Estimated Completion Date: 2028-12-31
Participants
Target number of participants: 200
Treatments
Patients with chronic coronary syndromes identified with intermediate grade coronary stenosis
Patients chronic coronary syndrome identified with intermediate grade coronary stenosis undergo coronary angiography according to current practice and guidelines recommendations. FFR will be measured, in consistency with the guidelines and recommended clinical practice. In case of FFR \> 0.8 optimal pharmacotherapy will be prescribed; on the contrary, in case of FFR ≤ 0.8 PCI will be performed. OCT imaging will be performed with commercially available device (Abbott, C7XR Dragonfly TM LightLab Imaging Inc., MA, USA) using the non-occlusive flushing technique.
Related Therapeutic Areas
Sponsors
Leads: Medical University of Warsaw

This content was sourced from clinicaltrials.gov