Rivaroxaban Post-Transradial Access for the Prevention of Radial Artery Occlusion

Who is this study for? Patients with Radial Artery Occlusion
What treatments are being studied? Rivaroxaban
Status: Recruiting
Location: See all (3) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

Coronary angiography is performed to evaluate for obstructive coronary artery disease. This is commonly performed via the transfemoral or transradial approach with the latter increasing in frequency. One of the most common complications of transradial access is radial artery occlusion occurring in \ 5% of patients which prohibits the use of the radial artery in the future. There is evidence to support the use of intraprocedural anticoagulation to mitigate the risk of radial artery occlusion however the role of post-procedural anticoagulation has not been previously evaluated. Rivaroxaban is a direct oral anticoagulant (DOAC) with a safety profile superior to that of vitamin K antagonists. Given the safety profile, ease of use, and feasibility of DOAC therapy, our study will endeavor to evaluate the use of rivaroxaban 15mg orally once daily for 7 days after transradial access and the impact this has on the rate of radial artery occlusion.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Willing and able to provide written informed consent

• Age ≥ 18 years

• Diagnostic coronary angiography or percutaneous coronary intervention via the transradial approach

Locations
United States
Minnesota
Mayo Clinic
RECRUITING
Rochester
Other Locations
Canada
Kingston Health Sciences Center
RECRUITING
Kingston
University of Ottawa Heart Institute
RECRUITING
Ottawa
Contact Information
Primary
Benjamin Hibbert, MD PhD
bhibbert@ottawaheart.ca
613-696-7280
Backup
Pietro Di Santo, MD
pdisanto@ottawaheart.ca
613-696-7280
Time Frame
Start Date: 2018-10-03
Estimated Completion Date: 2026-06-30
Participants
Target number of participants: 1800
Treatments
Experimental: Rivaroxaban
Participants will receive rivaroxaban 15mg tablet to be taken orally once daily for 7 days. Follow up will be within 30 days where participants will undergo a Doppler ultrasound to assess for radial artery patency/occlusion.
No_intervention: Standard of Care
Participants will not receive any anticoagulation. Follow up will be within 30 days where participants will undergo a Doppler ultrasound to assess for radial artery patency/occlusion.
Related Therapeutic Areas
Sponsors
Leads: Ottawa Heart Institute Research Corporation

This content was sourced from clinicaltrials.gov