A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing Olpasiran Use to Prevent First Major Cardiovascular Events in Participants With Elevated Lipoprotein(a)
Status: Recruiting
Location: See all (187) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp\[a\]).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Maximum Age: 105
Healthy Volunteers: f
View:
• Age ≥50 years
• Lp(a)≥ 200 nmol/L during screening
• Multiple atherosclerotic cardiovascular disease risk factors, and/or evidence of atherosclerosis
Locations
United States
Alabama
Advanced Cardiovascular LLC
RECRUITING
Alexander City
Alliance For Multispecialty Research - Daphne
RECRUITING
Daphne
Eastern Shore Research Institute
RECRUITING
Fairhope
Heart Center Research LLC
RECRUITING
Huntsville
CB Flock Research Corporation
RECRUITING
Mobile
Arizona
Elite Clinical Studies LLC
RECRUITING
Phoenix
Phoenix Clinical
RECRUITING
Phoenix
HonorHealth Research Institute
RECRUITING
Scottsdale
Eclipse Clinical Research
RECRUITING
Tucson
California
National Heart Institute
RECRUITING
Beverly Hills
310 Clinical Research
RECRUITING
Inglewood
University of California San Diego
RECRUITING
La Jolla
Valley Clinical Trials
RECRUITING
Northridge
Clinical Trials Research - Sacramento
RECRUITING
Roseville
Alliance Clinical Research
RECRUITING
San Diego
Encompass Clinical Research
RECRUITING
Spring Valley
Manshadi Heart Institute
RECRUITING
Stockton
Blue Coast Cardiology
RECRUITING
Vista
Diablo Clinical Research
RECRUITING
Walnut Creek
Focus Clinical Research
RECRUITING
West Hills
Colorado
South Denver Cardiology Associates
RECRUITING
Littleton
Connecticut
Chase Medical Research LLC
RECRUITING
Waterbury
Florida
Excel Medical Clinical Trials
RECRUITING
Boca Raton
Clearwater Cardiovascular Consultants
RECRUITING
Clearwater
Proactive Clinical Research
RECRUITING
Fort Lauderdale
Elite Cardiac Research Center LLC
RECRUITING
Hialeah
Indago Research and Health Center
RECRUITING
Hialeah
Jacksonville Center for Clinical Research
RECRUITING
Jacksonville
East Coast Institute for Research, LLC
RECRUITING
Lake City
Columbus Clinical Services LLC
RECRUITING
Miami
Kendall South Medical Center
RECRUITING
Miami
Inpatient Research Clinic, LLC
RECRUITING
Miami Lakes
Panax Clinical Research
RECRUITING
Miami Lakes
Eminat, LLC
RECRUITING
Miramar
Suncoast Clinical Research Inc
RECRUITING
New Port Richey
Ocala Cardiovascular Research
RECRUITING
Ocala
Ocala Research Institute, Inc
RECRUITING
Ocala
Ormond Beach Clinical Research
RECRUITING
Ormond Beach
Baptist Health Care
RECRUITING
Pensacola
Denali Health Plant City
RECRUITING
Plant City
Guardian Research Organization LLC
RECRUITING
Winter Park
Georgia
Emory University Hospital
RECRUITING
Atlanta
East Coast Institute for Research
RECRUITING
Canton
Northeast Georgia Medical Center Wisteria Building
RECRUITING
Cumming
Nsc Research
RECRUITING
Johns Creek
Iowa
MercyOne Iowa Heart Center
RECRUITING
West Des Moines
Idaho
Solaris Clinical Research
RECRUITING
Meridian
St Lukes Idaho Cardiology Associates
RECRUITING
Meridian
Illinois
Alliance for Multispecialty Research, LLC - Park Ridge
RECRUITING
Park Ridge
Indiana
MediSphere Medical Research Center LLC
RECRUITING
Evansville
Ascension Saint Vincent Heart Center
RECRUITING
Indianapolis
Franciscan Health Indianapolis
RECRUITING
Indianapolis
Cardiovascular Research of Northwest Indiana LLC
RECRUITING
Munster
Reid Physician Associates
RECRUITING
Richmond
Kansas
Hutchinson Clinic PA
RECRUITING
Hutchinson
University of Kansas Medical Center
RECRUITING
Kansas City
Midwest Heart and Vascular Specialists
RECRUITING
Overland Park
Kentucky
Graves Gilbert Clinic
RECRUITING
Bowling Green
The Research Group of Lexington LLC
RECRUITING
Lexington
Louisiana
Heart Clinic of Hammond
RECRUITING
Covington
Ima Clinical Research
RECRUITING
Monroe
Louisiana Heart Center
RECRUITING
Slidell
Monroe Research LLC
RECRUITING
West Monroe
Massachusetts
Brigham and Womens Hospital
RECRUITING
Boston
Maryland
Ascension Saint Agnes Heart Care
RECRUITING
Baltimore
Johns Hopkins Hospital
RECRUITING
Baltimore
Metropolitan Cardiovascular Consultants LLC
RECRUITING
Beltsville
Suburban Hospital
RECRUITING
Bethesda
Flourish Research
RECRUITING
Bowie
Centennial Medical Group
RECRUITING
Columbia
Johns Hopkins University
RECRUITING
Columbia
Capitol Cardiology Associates
RECRUITING
Lanham
Michigan
MyMichigan Medical Center Midland - Clinical Research Department
RECRUITING
Midland
Advanced Cardiology Associates
RECRUITING
Rochester Hills
Revival Research Institute
RECRUITING
Southfield
Minnesota
Mayo Clinic
RECRUITING
Rochester
Methodist Hospital
RECRUITING
Saint Louis Park
Missouri
Sisters of Saint Mary Health Heart and Vascular Care
RECRUITING
Bridgeton
Washington University
RECRUITING
St Louis
Mississippi
Jackson Heart Clinic
RECRUITING
Jackson
Cardiology Associates Research LLC
RECRUITING
Tupelo
North Carolina
Medication Management LLC
RECRUITING
Greensboro
Moses H Cone Memorial Hospital
RECRUITING
Greensboro
Triad Clinical Trials, LLC
RECRUITING
Greensboro
Monroe Biomedical Research
RECRUITING
Monroe
Accellacare Research of Wilmington
RECRUITING
Wilmington
Nebraska
Bryan Heart
RECRUITING
Lincoln
New Jersey
Advanced Heart and Vascular Institute of Hunterdon
RECRUITING
Flemington
Med Clinical Research Partners - Irvington
RECRUITING
Irvington
New Jersey Medcare / New Jersey Heart
RECRUITING
Linden
Saint Michaels Medical Center
RECRUITING
Newark
Circuit Clinical / Optum Medical Care of New Jersey
RECRUITING
Secaucus
The Heart House - Washington Township
RECRUITING
Sewell
CardioMetabolic Collaborative Clinic
RECRUITING
Somerset
Ima Clinical Research - Warren
RECRUITING
Warren Township
Nevada
American Institute of Medical Research
RECRUITING
Las Vegas
Excel Clinical Research
RECRUITING
Las Vegas
Las Vegas Clinical Trials
RECRUITING
North Las Vegas
Renown Institute for Heart and Vascular Health
RECRUITING
Reno
New York
Albany Medical College
RECRUITING
Albany
Crystal Run Healthcare
RECRUITING
Monroe
Ima Clinical Research Manhattan
RECRUITING
New York
Niagara Falls Memorial Medical Center
RECRUITING
Niagara Falls
Orchard Park Family Pracitce
RECRUITING
Orchard Park
Saratoga Clinical Research, LLC
RECRUITING
Saratoga Springs
Ohio
Aultman Cardiology Clinical Trials
RECRUITING
Canton
The Christ Hospital
RECRUITING
Cincinnati
Velocity Clinical Research - Cincinnati
RECRUITING
Cincinnati
Nexgen Research
RECRUITING
Lima
K and R Research
RECRUITING
Marion
Oklahoma
Alliance for Multispecialty Research
RECRUITING
Norman
Pennsylvania
Pottstown Medical Specialists Inc
RECRUITING
Pottstown
South Carolina
Pharmacorp Clinical Trials Inc
RECRUITING
Charleston
Prisma Health Carolina Cardiology - Greenville
RECRUITING
Gantt
Walker Family Care
RECRUITING
Little River
Accellacare Charleston
RECRUITING
Mt. Pleasant
Tribe Clinical Research - Spartanburg
RECRUITING
Spartanburg
Tennessee
Erlanger Health, Inc.
RECRUITING
Chattanooga
Apex Research Foundation, LLC
RECRUITING
Jackson
Alliance for Multispecialty Research Knoxville
RECRUITING
Knoxville
Ascension Saint Thomas
RECRUITING
Nashville
Parkway Cardiology Associates
RECRUITING
Oak Ridge
Tennessee Center for Clinical Trials
RECRUITING
Tullahoma
Texas
PharmaTex Research, LLC
RECRUITING
Amarillo
Ima Clinical Research
RECRUITING
Austin
Texas Diabetes and Endocrinology
RECRUITING
Austin
Pioneer Medical Associates
RECRUITING
Carrollton
Baylor Scott and White Heart and Vascular Hospital-Dallas
RECRUITING
Dallas
Cedar Health Research, LLC
RECRUITING
Dallas
Zenos Clinical Research
RECRUITING
Dallas
Cedar Health Research, LLC
RECRUITING
Euless
Baylor College of Medicine
RECRUITING
Houston
Cardiovascular Specialists of Willowbrook
RECRUITING
Houston
East Texas Cardiology PA
RECRUITING
Houston
Vital Heart and Vein
RECRUITING
Humble
Tcr Institute Llc
RECRUITING
Kingwood
Epic Clinical Research
RECRUITING
Lewisville
North Dallas Research Associates
RECRUITING
Mckinney
Texas Institute of Cardiology
RECRUITING
Mckinney
Southern Endocrinology Associates PA
RECRUITING
Mesquite
Orion Medical
RECRUITING
Pasadena
Valley Institute of Research Plano
RECRUITING
Plano
Ima Clinical Research San Antonio
RECRUITING
San Antonio
Revival Research Institute
RECRUITING
Sherman
Tyler Cardiovascular Consultants
RECRUITING
Tyler
Utah
Alpine Research Organization
RECRUITING
Layton
Virginia
Carient Heart and Vascular
RECRUITING
Manassas
Tidewater Physicians Multispecialty Group Clinical Research
RECRUITING
Newport News
Alliance for Multispecialty Research Norfolk
RECRUITING
Norfolk
Centricity Research
RECRUITING
Suffolk
Selma Medical Associates
RECRUITING
Winchester
Winchester Medical Center
RECRUITING
Winchester
Other Locations
Australia
Advara HeartCare Wesley
RECRUITING
Auchenflower
Flinders Medical Centre
RECRUITING
Bedford Park
Royal Prince Alfred Hospital
RECRUITING
Camperdown
Novatrials
RECRUITING
Charlestown
Victorian Heart Hospital
RECRUITING
Clayton
Concord Repatriation General Hospital
RECRUITING
Concord
Advara HeartCare Joondalup
RECRUITING
Joondalup
Advara HeartCare Leabrook
RECRUITING
Leabrook
Momentum Clinical Research - Sunshine
RECRUITING
Melbourne
The Alfred Hospital
RECRUITING
Melbourne
Aim Research
RECRUITING
Merewether
Core Research Group Pty Ltd
RECRUITING
Milton
Hollywood Private Hospital
RECRUITING
Nedlands
Linear Clinical Research Limited
RECRUITING
Nedlands
Fusion Clinical Research
RECRUITING
Norwood
Orange Health Service
RECRUITING
Orange
Clinitrials - Mount Medical Centre
RECRUITING
Perth
University of The Sunshine Coast Clinical Trials, Sippy Downs
RECRUITING
Sippy Downs
Dr Heart Pty Ltd
RECRUITING
Woolloongabba
Canada
Centricity Research Brampton
RECRUITING
Brampton
Centricity Research Calgary
RECRUITING
Calgary
Ecogene-21
RECRUITING
Chicoutimi
Edmonton Cardiology Consultants
RECRUITING
Edmonton
Premier Clinical Trial Network
RECRUITING
Hamilton
Elevate Clinical Research KMH Missisauga
RECRUITING
Mississauga
Institut de recherches cliniques de Montreal
RECRUITING
Montreal
Fraser Clinical Trials
RECRUITING
New Westminster
Partners in Advanced Cardiac Evaluation
RECRUITING
Newmarket
North York Diagnostic and Cardiac Centre
RECRUITING
North York
Oakville Cardiovascular Research
RECRUITING
Oakville
Heart Health Institute Research Incorporated
RECRUITING
Scarborough Village
CIUSSS de l Estrie CHUS Hopital Fleurimont
RECRUITING
Sherbrooke
SMH Cardiology Clinical Trials Incorporated
RECRUITING
Surrey
ARC Biosystems Incorporated
RECRUITING
Vancouver
Discovery Clinical Services Ltd
RECRUITING
Victoria
Contact Information
Primary
Amgen Call Center
medinfo@amgen.com
866-572-6436
Time Frame
Start Date: 2025-08-22
Estimated Completion Date: 2031-10-20
Participants
Target number of participants: 11000
Treatments
Experimental: Olpasiran
Participants will receive subcutaneous (SC) olpasiran.
Placebo_comparator: Placebo
Participants will receive SC placebo.
Related Therapeutic Areas
Sponsors
Leads: Amgen