COVID-19 Clinical Trials

• 18 years of age or older at screening who are non-hospitalized or hospitalized for observation or with the intent of administering the study intervention.

• Confirmed SARS-CoV-2 infection as determined by RAT (or other locally approved test) collected within 2 days prior to randomization. Initial onset of symptoms attributable to COVID-19 within 5 days prior to the day of randomization and at least 1 of the specified symptoms attributable to COVID-19 present on the day of randomization.

• Severely immunocompromised due to:

‣ Solid organ or islet cell transplant recipient who is receiving immunosuppressive therapy;

⁃ Active hematologic malignancy (eg, chronic lymphocytic leukemia, non-Hodgkin lymphoma, multiple myeloma, acute leukemia);

⁃ Receipt of CAR-T-cell therapy or HCT either within 2 years of transplantation or who are receiving immunosuppressive therapy;

⁃ Currently receiving or recently received B-cell depleting therapies (eg, rituximab), where the immunosuppressive effect is still ongoing.