Metabolomics Pilot Study on Postoperative Intensive Care Acquired Muscle Weakness (MIRACLE-I Study)
Status: Recruiting
Location: See all (3) locations...
Study Type: Observational
SUMMARY
In this mono-center pilot trial, surgical patients who are at high risk to be admitted to intensive care will be screened and asked for participation. We are going to take blood and muscle samples at respecified time points to do metabolic, histological and molecular testing. Aim of the study is to investigate (1) changes of the blood metabolome in patients with ICUAW (intensive care unit acquired weakness) and (2) identify metabolic components who are responsible for ICUAW or can be used as marker for ICUAW.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
View:
• invasive mechanically ventilated critically ill patient with expected intensive care unit stay \> 3 days
• postoperative patient
• ≥ 18 years old
• American Society of Anesthesiology (ASA) classification ≥ III
Locations
Other Locations
Austria
Medical University of Vienna
RECRUITING
Vienna
Germany
Charité - Universitätsmedizin Berlin
RECRUITING
Berlin
Klinikum rechts der Isar, School of Medicine, Technical University of Munich
ACTIVE_NOT_RECRUITING
Munich
Contact Information
Primary
Stefan J Schaller, MD
s.schaller@tum.de
+49-89-4140-9635
Backup
Manfred Blobner, MD
m.blobner@tum.de
+49-89-4140-7206
Time Frame
Start Date: 2022-09-02
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 20
Treatments
Intensive Care Patients
Postoperative high-risk patients who have been admitted to intensive care after surgery
Operative Control patients
Elective operative patients where control blood samples and muscle ultrasound will be measured.
Related Therapeutic Areas
Sponsors
Collaborators: Medical University of Vienna, Charite University, Berlin, Germany, Helmholtz Zentrum München
Leads: Technical University of Munich