Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations (ITACA Study)
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY
The investigators hypothesize that cardiovascular and metabolic alterations can occur in patients with adrenal adenomas and possible Autonomous Cortisol Secretion (pACS). Investigators hypothesize that adrenalectomy in selected patients, following the 2016 European Congress of Endocrinology (ECE) guidelines, can improve metabolic parameters and cardiovascular risks and features.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: t
View:
• Incidentally detected adrenal mass
Locations
Other Locations
Italy
Department of Experimental Medicine
RECRUITING
Rome
Time Frame
Start Date: 2019-01-02
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 68
Treatments
Patients with non-functioning adrenal adenoma
Patients with incidentally discovered adrenal mass with 1mg-DST serum cortisol levels lower than 50 nmol/L
Patients with pACS receiving conservative management
Patients with incidentally discovered adrenal mass with 1mg-DST serum cortisol levels greater than 50 nmol/L receiving conservative management
Patients with pACS receiving adrenalectomy
Patients with incidentally discovered adrenal mass with 1mg-DST serum cortisol levels greater than 50 nmol/L receiving adrenalectomy according to the 2016 European Society of Endocrinology guidelines
Healthy controls
Patients without adrenal masses
Related Therapeutic Areas
Sponsors
Leads: University of Roma La Sapienza