The Impact of Sinus Surgery in the Era of Highly Effective Modulatory Therapy
Status: Recruiting
Location: See all (9) locations...
Study Type: Observational
SUMMARY
This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS). Individuals who do not undergo surgery but are treated medically for CRS will also be enrolled to serve as a control group. Outcomes analyzed will include pulmonary, quality of life, and others.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 99
Healthy Volunteers: f
View:
• Subjects between the ages of 18 years old (inclusive) and 99 years old (inclusive, subjects over the age of 89 will be recorded to be 89 years old).
• Diagnosed with cystic fibrosis as established by genetic testing combined with clinical assessment and/or sweat chloride
• Diagnosed with chronic rhinosinusitis by multidisciplinary sinusitis guidelines
• chronic rhinosinusitis symptoms persisting beyond initial medical treatment
• Counseled for endoscopic sinus surgery and ongoing medical therapy with each patient electing their preferred treatment
Locations
United States
California
University of California, Los Angeles
RECRUITING
Los Angeles
Stanford University
RECRUITING
Stanford
Colorado
University of Colorado
RECRUITING
Aurora
National Jewish Health
RECRUITING
Denver
North Carolina
University of North Carolina
RECRUITING
Chapel Hill
Oregon
Oregon Health Science University
RECRUITING
Portland
South Carolina
Medical University of South Carolina
RECRUITING
Charleston
Tennessee
Vanderbilt University Medical Center
RECRUITING
Nashville
Utah
University of Utah
RECRUITING
Salt Lake City
Contact Information
Primary
Daniel M Beswick, MD
dbeswick@mednet.ucla.edu
310-206-8457
Backup
Marlene Florian
mflorian@mednet.ucla.edu
424-946-5862
Time Frame
Start Date:2020-07-01
Estimated Completion Date:2027-01-31
Participants
Target number of participants:170
Treatments
Surgical group
Individuals with cystic fibrosis and chronic rhinosinusitis who undergo endoscopic sinus surgery
Medical group
Individuals with cystic fibrosis and chronic rhinosinusitis who do not undergo endoscopic sinus surgery