Kidney Function in People With Cystic Fibrosis in the Era of HEMT
The purpose of this study is to find out what causes kidney disease in people with CF. The investigators will study biomarkers in the blood and urine that can either predict who is at risk or detect kidney damage early before it becomes permanent. The study will compare these markers in people with CF over time and during the treatment of lung flare-ups. It will also compare the blood and urine samples obtained from people without CF. The comparison aims to better understand the impact of cystic fibrosis and its treatment on the kidneys, as well as to develop improved methods for preventing, diagnosing, and treating kidney issues associated with CF.
• Outpatient CF Cohort
‣ Diagnoses of Cystic Fibrosis
⁃ Age \> 30 years old
⁃ Able to provide informed consent
• Inpatient CF Cohort
‣ Diagnoses of Cystic Fibrosis
⁃ Age \> 7 years old
⁃ Able to provide informed consent and assent (where applicable)
⁃ 55 PwCF frequently hospitalized for a pulmonary exacerbation (\>1 hospital admission in the prior 12 months)
⁃ 55 PwCF sporadically hospitalized for a pulmonary exacerbation (no hospital admissions in the prior 12 months)
⁃ Able to provide urine sample independently
• Healthy Controls
‣ Healthy, as per participant self-report
⁃ Age between 30-50 years
⁃ Able to provide informed consent