MAGNIFY - Pulmonary Magnetic Resonance Imaging for Cystic Fibrosis
This research study is looking at new ways of measuring the function of the lungs in patients with cystic fibrosis. This study is using the most advanced methods for measuring lung function including 2 tests called hyperpolarised gas magnetic resonance imaging (HP MRI) and multiple breath washout (MBW), to better understand changes in the lungs over time. HP MRI involves taking pictures of the air in your lungs after breathing in a harmless gas (xenon). MBW is a breathing test used to calculate something called the lung clearance index (LCI). By measuring these tests on the same day, alongside standard lung function tests, we aim to understand lung function in greater detail than ever before.
⁃ For eligibility into MAGNIFY, subjects should meet all of the following criteria:
• A confirmed clinical diagnosis of CF, consisting of 2 confirmed disease-causing CFTR mutations along with either positive sweat chloride (\>60mmol/L, measured before starting CFTR modulator therapy) or a clinical picture consistent with CF as judged by a senior CF physician. Patients will be under one of named regional CF centres above.
• Be able to attend the local facility for scans (Royal Hallamshire Hospital, Sheffield).
⁃ For eligibility into 129Xe-MRI and lung function (cohort 1,2 and 3)
• Aged 5 years and above
• FEV1 \>30% predicted (best in the previous 6 months) For eligibility for cohort 1
⁃ 1\. Previous participation in the MMAVIC study, with at least one prior visit where lung ventilation MRI was successfully measured.
⁃ For eligibility into cohort 4 for 1H MRI only:
⁃ 1\. Aged between 1 and 5 years of age