A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge. Older ICU survivors (ages 60 and older) are at highest risk for delirium and subsequent cognitive impairment, which contribute to higher risk for cognitive decline related to Alzheimer's disease and related dementias. Sleep and activity are essential for recovery from critical illness, yet ICU survivors experience both sleep deficiency and profound inactivity. About 75-80% of ICU patients experience circadian dysrhythmia, which contributes to cognitive decline and increases likelihood of developing Alzheimer's disease and related dementias. The scientific premises of the proposed study are: 1) a combined sleep promotion and cognitive training intervention will have synergistic effects to mitigate the risk of cognitive impairment and development of Alzheimer's disease and related dementias in older ICU survivors; and 2) chronotherapeutic timing of interventions (i.e., adjusting timing of interventions according to circadian rhythm) may improve intervention efficacy.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 60
Healthy Volunteers: f
View:

• Age greater than or equal to 60 years old

• Current hospitalization at University of Washington Medical Center or Harborview Medical Center

• Intensive care unit (ICU) length of stay greater than 24 hours

• Recovery from critical care status to acute care status, and/or discharge out of ICU

• Fluent in English or Spanish

• Functional independence on activities of daily living prior to hospitalization (Katz Index = 6)

Locations
United States
Washington
University of Washington
RECRUITING
Seattle
Contact Information
Primary
Maya N Elias, PhD, MA, RN
mnelias@uw.edu
206-543-8564
Time Frame
Start Date: 2024-12-26
Estimated Completion Date: 2027-05-31
Participants
Target number of participants: 100
Treatments
Experimental: SLEEP + COG
* Combination of SLEEP and COG interventions, for up to 7 days/nights + usual post-ICU inpatient care~* Personalized timing of morning, afternoon, or evening COG sessions, based on CSM scale at baseline
Experimental: COG
* Daily 30-minute computerized cognitive training sessions (Lumosity), for up to 7 days + usual post-ICU inpatient care~* Personalized timing of morning, afternoon, or evening COG intervention sessions, based on CSM scale at baseline
Experimental: SLEEP
\- Nighttime use of earplugs and eye masks, for up to 7 nights + usual post-ICU inpatient care
Active_comparator: AC
\- Active comparator condition; delivery of educational modules on brain health + usual post-ICU inpatient care
Related Therapeutic Areas
Sponsors
Collaborators: National Institute on Aging (NIA)
Leads: University of Washington

This content was sourced from clinicaltrials.gov