Effect of Different Administration Routes of Dexmedetomidine Combined with Ultrasound-Guided Fascia Iliaca Block on Emergence Agitation After Hip Replacement Surgery
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 1
SUMMARY
To examine the impact of various administration routes of dexmedetomidine in conjunction with ultrasound-guided fascia iliaca block (FIB) on emergence agitation (EA) during the postoperative recovery period after hip replacement surgery.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:
• age between 18 and 65 years, with no restriction on gender
• diagnosis of hip joint disease necessitating hip arthroplasty
• ASA grade I-II
• no significant cardiopulmonary, hepatic, or renal dysfunction prior to the operation
• no history of psychiatric disorders or long-term use of sedative medications prior to the operation
• signing of an informed consent form to voluntarily participate in the study.
Locations
Other Locations
China
Qianfoshan Hospital
RECRUITING
Jinan
Contact Information
Primary
Pengcai Shi, Chief physician
shipc1997@163.com
13791126828
Time Frame
Start Date: 2023-02-05
Estimated Completion Date: 2025-12-01
Participants
Target number of participants: 207
Treatments
Experimental: Group S1
Before anesthesia induction, an iliac fascia block was administered using 0.375% ropivacaine (30 mL) under ultrasound guidance, followed by conventional anesthesia induction. During the anesthesia maintenance phase, dexmedetomidine was infused intravenously at a rate of 0.5 µg/kg/h.
Experimental: Group S2
Before anesthesia induction, an iliac fascia block was administered using a mixture of 0.375% ropivacaine and 1ug/kg dexmedetomidine (30ml) under ultrasound guidance. During the anesthesia maintenance phase, an equivalent volume of 0.9% sodium chloride injection was infused intravenously.
Active_comparator: Group C
Before anesthesia induction, an iliac fascia block was performed using 0.375% ropivacaine (30 mL) under ultrasound guidance, followed by conventional anesthesia induction. During the anesthesia maintenance phase, an equivalent volume of 0.9% sodium chloride injection was infused intravenously.
Related Therapeutic Areas
Sponsors
Leads: Qianfoshan Hospital