PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr Adults (PREVENTABLE)
Who is this study for? Healthy adults over 75
What treatments are being studied? Atorvastatin
Status: Recruiting
Location: See all (103) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the benefit of statins for reducing the primary composite of death, dementia, and persistent disability and secondary composites including mild cognitive impairment (MCI) and cardiovascular events.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 75
Healthy Volunteers: t
View:
• Community-dwelling adults
• Age ≥75 years
• English or Spanish as primary language
• Able to provide a trusted contact
Locations
United States
Alabama
Birmingham VA
RECRUITING
Birmingham
University of Alabama at Birmingham
RECRUITING
Birmingham
Arkansas
Little Rock VA Medical Center
RECRUITING
Little Rock
University of Arkansas for Medical Sciences
RECRUITING
Little Rock
Arizona
Southern Arizona VA Health Care System - Tucson
RECRUITING
Tucson
California
Fresno VA Medical Center
RECRUITING
Fresno
Long Beach VA Medical Center
RECRUITING
Long Beach
Cedars-Sinai Medical Center
NOT_YET_RECRUITING
Los Angeles
VA Greater Los Angeles
RECRUITING
Los Angeles
VA Palo Alto Healthcare System
WITHDRAWN
Palo Alto
VA San Diego Medical Center
RECRUITING
San Diego
Connecticut
Yale University
RECRUITING
New Haven
VA Connecticut Healthcare System
RECRUITING
West Haven
Florida
Bay Pines VA
RECRUITING
Bay Pines
Gainesville VA Medical Center
RECRUITING
Gainesville
University of Florida
RECRUITING
Gainesville
University of Florida
RECRUITING
Jacksonville
Miami VA Medical Center
RECRUITING
Miami
University of Miami
RECRUITING
Miami
Georgia
Atlanta VA Medical Center
RECRUITING
Atlanta
Emory University
RECRUITING
Atlanta
Iowa
University of Iowa Healthcare
RECRUITING
Iowa City
Illinois
Chicago VA Medical Center/Jesse Brown VA
WITHDRAWN
Chicago
Northwestern University
RECRUITING
Chicago
Rush University Medical Center
RECRUITING
Chicago
University of Chicago
RECRUITING
Chicago
University of Illinois at Chicago
RECRUITING
Chicago
Hines VA Medical Center
RECRUITING
Hines
North Chicago VA Medical Center
RECRUITING
North Chicago
Indiana
Indianapolis VA Medical Center
RECRUITING
Indianapolis
Kansas
Kansas City VA Medical Center
RECRUITING
Kansas City
University of Kansas Medical Center
RECRUITING
Kansas City
VA Eastern Kansas Healthcare System
NOT_YET_RECRUITING
Topeka
Kentucky
Louisville VA Medical Center
RECRUITING
Louisville
Louisiana
Ochsner Clinic Foundation
RECRUITING
New Orleans
University Medical Center
COMPLETED
New Orleans
Massachusetts
VA Boston Healthcare System
RECRUITING
Boston
Maryland
Johns Hopkins University
RECRUITING
Baltimore
Maine
Maine VA Health Care System
RECRUITING
Togus
Michigan
University of Michigan
RECRUITING
Ann Arbor
VA Ann Arbor Healthcare System
RECRUITING
Ann Arbor
Minnesota
Essentia Health
RECRUITING
Duluth
Allina Health
ACTIVE_NOT_RECRUITING
Minneapolis
Minneapolis VA Health Care System
WITHDRAWN
Minneapolis
Mayo Clinic
RECRUITING
Rochester
Missouri
University of Missouri Health System
RECRUITING
Columbia
St. Louis VA Medical Center
RECRUITING
St Louis
Washington University in St. Louis
RECRUITING
St Louis
Mississippi
University of Mississippi Medical Center
RECRUITING
Jackson
VA Medical Center Jackson
RECRUITING
Jackson
North Carolina
Asheville VA-Charles George VA Medical Center
RECRUITING
Asheville
University of North Carolina
RECRUITING
Chapel Hill
Atrium Health
RECRUITING
Charlotte
Duke University
RECRUITING
Durham
Durham VA Medical Center
RECRUITING
Durham
PREVENTABLE Tele-Site
RECRUITING
Durham
Duke University - Kannapolis
RECRUITING
Kannapolis
Wake Forest Baptist Hospital-Cardiology
RECRUITING
Winston-salem
Wake Forest Hospital - Geriatrics
RECRUITING
Winston-salem
Nebraska
Omaha VA Medical Center
RECRUITING
Omaha
University of Nebraska Medical Center
RECRUITING
Omaha
Nevada
Reno VA/Sierra Nevada Health Care
WITHDRAWN
Reno
New York
Northwell Health
RECRUITING
Manhasset
VA Hudson Valley Healthcare System
WITHDRAWN
Montrose
VA New York Harbor Healthcare System
NOT_YET_RECRUITING
New York
Weill Cornell Medical College
RECRUITING
New York
Albert Einstein College of Medicine
RECRUITING
The Bronx
Bronx VA Medical Center
WITHDRAWN
The Bronx
Ohio
Cincinnati VA Medical Center
RECRUITING
Cincinnati
Case Western Reserve University
RECRUITING
Cleveland
Ohio State University
RECRUITING
Columbus
Dayton VA Medical Center
RECRUITING
Dayton
Oregon
Oregon Health and Science University
NOT_YET_RECRUITING
Portland
Pennsylvania
Corporal Michael J. Crescenz VA Medical Center-Philadelphia VA
WITHDRAWN
Philadelphia
Thomas Jefferson University
NOT_YET_RECRUITING
Philadelphia
University of Pittsburgh Medical Center
RECRUITING
Pittsburgh
Rhode Island
Providence VA Medical Center
RECRUITING
Providence
South Carolina
Charleston VA Medical Center
RECRUITING
Charleston
Medical University of South Carolina
RECRUITING
Charleston
Columbia VA Health Care/Dorn VA Medical Center
RECRUITING
Columbia
Tennessee
VA Medical Center Memphis
RECRUITING
Memphis
Meharry Medical College
RECRUITING
Nashville
Nashville VA Medical Center
RECRUITING
Nashville
Vanderbilt University Medical Center
RECRUITING
Nashville
Texas
Baylor Scott and White Medical Center
RECRUITING
Dallas
Dallas VA Medical Center
RECRUITING
Dallas
University of Texas Southwestern Medical Center Dallas
RECRUITING
Dallas
Doctors Hospital at Renaissance
RECRUITING
Edinburg
University of Texas at Houston
RECRUITING
Houston
San Antonio VA Medical Center
RECRUITING
San Antonio
University of Texas Health Science Center at San Antonio
RECRUITING
San Antonio
Utah
Intermountain
RECRUITING
Murray
University of Utah
ACTIVE_NOT_RECRUITING
Salt Lake City
VA Salt Lake City Healthcare System
RECRUITING
Salt Lake City
Virginia
Richmond VA
RECRUITING
Richmond
Wisconsin
Mayo Clinic Health Systems - NW Wisconsin
RECRUITING
Eau Claire
Mayo Clinic Health System SW Wisconsin
RECRUITING
La Crosse
VA Madison Healthcare System
RECRUITING
Madison
Marshfield Clinic
RECRUITING
Marshfield
Medical College of Wisconsin
RECRUITING
Milwaukee
Milwaukee VA Medical Center
RECRUITING
Milwaukee
West Virginia
Clarksburg VA Medical Center
WITHDRAWN
Clarksburg
Other Locations
Puerto Rico
VA Carribbean Healthcare
RECRUITING
San Juan
Contact Information
Primary
Pamela Monds
pamela.monds@duke.edu
9196688695
Backup
Beth Harris
Elizabeth.C.Harris@duke.edu
9196688700
Time Frame
Start Date: 2020-09-01
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 20000
Treatments
Experimental: atorvastatin 40mg
40mg atorvastatin po qd from consent to study end
Placebo_comparator: Placebo
matching placebo po qd from consent to study end
Authors
Lisa Trevino, Cynthia Chuang, Carrie Pohl, Drew Purdy, Subbarao Pemmaraju, Philip Binkley, Catherine McNeal, Jonathan Gugel, June McKoy, Steven Atlas, E. Camille Vaughan, Christine Kistler, Bruce Kinosian, Anna Paszczuk, Mitchell Finkel, J. Brent Muhlestein, Veronique Roger, Jeffrey Whittle, Vijay Shivaswamy, Angelike Liappis, Marivic Sumulong-Tomacruz, Richard Pratley, Clint Allred, Bhaskar Purushottam, Zhenguo Liu
Related Therapeutic Areas
Sponsors
Collaborators: Wake Forest University Health Sciences, National Institute on Aging (NIA), National Heart, Lung, and Blood Institute (NHLBI)
Leads: Duke University