RCT Targeting Cognition in Early Alzheimer's Disease by Improving Sleep With Trazodone (REST)
To investigate the effect of trazodone on sleep, hippocampal-dependent memory and hippocampal excitability. The investigators hypothesize that trazodone will improve total sleep time and proportion of time in Slow Wave Sleep (SWS).
• Mild Cognitive Impairment (MCI) as defined by Albert et al.2 including subjective memory complaint and/or objective evidence of memory problems;
• Clinical Dementia Rating (CDR) of 0.5 with a Memory Box score of \>=0.5;
• Evidence of sleep complaints with Pittsburgh Sleep Quality Index score of \>5 (a well-validated cutoff observed in \>40% of older persons);
• Memory performance \> 1.5 Standard Deviation (SD) below age-and education-matched control subjects on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) List Recall;
• Visual and auditory acuity adequate for neuropsychological testing;
• Good general health with no disease expected to interfere with the study;
• Able to have Magnetic Resonance Imaging (MRI) scan;
• Availability of knowledgeable informant (KI)