Shanghai At Risk for Alzheimer's Disease: a Cohort Study
The goal of this cohort study is to estimate the incidence of AD in the first-degree relatives of patients with AD. The main questions it aims to answer are: * cognitive changes of subjects at high risk of AD as ageing; * environmental and behavioral factors affecting AD incidence.
• the AD diagnostic criteria of probands meet the 2011 National Institute on Aging - Alzheimer's Association framework, and participants are the first-degree relatives (including parents, children and siblings of the same father and mother) of the proband;
• not patients with dementia;
• ≥ 50 years, males and females;
• subjects have lived in Shanghai for more than 1 year and have no plan to move out of Shanghai within 5 years;
• subjects are able to complete investigation, physical examination, imaging examination and biological specimen collection.