Clinical Applicability of Pseudo-continuous Arterial Spin Labeling as a Substitute for FDG-position Emission Tomography in MCI and SCD Patients

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

The goal of this observational study is to compare cerebral perfusion patterns with pseudo-continuous arterial spin labeling (pCASL) and brain metabolism patterns with fluorodeoxyglucose-position emission tomography (FDG-PET) in patients with mild cognitive impairment (MCI) and subjective cognitive decline (SCD). The main questions it aims to answer are: * Do pCASL sequences identify hypoperfusion patterns that correlate well with FDG-PET hypometabolic patterns? * Are there differences in this correlation in terms of cerebrospinal fluid (CSF) profiles? * Can hypoperfusion patterns in pCASL predict conversion to dementia? Participants will undergo brain 3 Tesla magnetic resonance imaging (MRI), FDG-PET, lumbal puncture and blood collection to analyze amyloid beta and tau, yearly detailed neuropsychological tests for three years.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• Patients with mild cognitive impairment or subjective cognitive decline according to established criteria

• Clinical Dementia Rating scale of 0 or 0.5

• Signed informed consent before study entry

Locations
Other Locations
Italy
Fondazione IRCCS San Gerardo dei Tintori
RECRUITING
Monza
Contact Information
Primary
Carlo Ferrarese, MD, PhD
carlo.ferrarese@unimib.it
+390392333595
Time Frame
Start Date: 2022-06-03
Estimated Completion Date: 2026-06
Participants
Target number of participants: 150
Related Therapeutic Areas
Sponsors
Leads: University of Milano Bicocca

This content was sourced from clinicaltrials.gov