Greater-Bay-Area Healthy Aging Brain Study (GHABS): Biomarker- and Neuroimaging-based Study of the Pathophysiology Characterization and Evolutionary Patterns of Alzheimer's Disease
The goal of this observational study is to learn about the pathophysiology characterization and evolutionary patterns of Alzheimer's disease (AD) in South China older adults. The primary purposes are as follows: 1. The prevalence and characteristics of AD in South China's aging population 2. Identify novel biomarkers and neuroimaging techniques for early detection and intervention of AD 3. Supporting and fertilizing novel approaches and techniques for early diagnosis and intervention of AD Participants will undergo cognitive assessments, blood sample collection, and genetic testing. Some will undergo CSF collection, stool sample collection, MRI scanning, Aβ PET scanning, and tau PET scanning.
• This project intends to recruit men and women between the ages of 55 and 90. The inclusion criteria are as listed:
• Age 55-90 years old (including 55 and 90 years old). However, people with autosomal dominant and other familial Alzheimer disease (FAD) are not limited by age.
• The score of the Geriatric Depression Scale (GDS) is less than 6 points.
• There is a caregiver who can maintain at least 10 hours of contact per week and can accompany volunteers to the test site for testing.
• Visual and auditory acuity is sufficient for neuropsychological testing. (Including normal corrected vision and hearing)
• Be in good health and are expected to be free of disease interference during the study.
• Volunteers are not pregnant, lactating or have reproductive potential (that is, women must be two years after menopause or undergo sterilization surgery).
• Willingness and ability to participate in longitudinal imaging studies.
• A modified version of the Hachinski Ischemic scores less than or equal to 4.
• Have completed grade 6 education or have good work experience (sufficient to rule out mental retardation).
• Must be able to speak Mandarin fluently.
• Willing to undergo multiple 3T MRI scans and at least two PET scans.
• Agree to collect blood for genomic analysis (including GWAS sequencing and other analyses), AD risk and protective genes such as apolipoprotein E (APOE), klotho, etc., and biological sample storage.
• Agree to collect blood for biomarker detection.
• Agree to share genomic data and biomarker samples.